SLANINA, Jiří, Eva TÁBORSKÁ, Hana BOCHOŘÁKOVÁ, Iva SLANINOVÁ, Otakar HUMPA, W. Edward ROBINSON and Karl H. SCHRAM. New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid. Tetrahedron Letters. Oxford: Pergamon - Elsevier Science, 2001, vol. 42, No 19, p. 3383-6767. ISSN 0040-4039. |
Other formats:
BibTeX
LaTeX
RIS
@article{365191, author = {Slanina, Jiří and Táborská, Eva and Bochořáková, Hana and Slaninová, Iva and Humpa, Otakar and Robinson, W. Edward and Schram, Karl H.}, article_location = {Oxford}, article_number = {19}, keywords = {Antivirals; biologically active compounds; isomerisation; phenolics; tannins}, language = {eng}, issn = {0040-4039}, journal = {Tetrahedron Letters}, title = {New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid}, volume = {42}, year = {2001} }
TY - JOUR ID - 365191 AU - Slanina, Jiří - Táborská, Eva - Bochořáková, Hana - Slaninová, Iva - Humpa, Otakar - Robinson, W. Edward - Schram, Karl H. PY - 2001 TI - New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid JF - Tetrahedron Letters VL - 42 IS - 19 SP - 3383 EP - 3383 PB - Pergamon - Elsevier Science SN - 00404039 KW - Antivirals KW - biologically active compounds KW - isomerisation KW - phenolics KW - tannins N2 - A facile and inexpensive preparation of 1,3-dicaffeoylquinic acid (cynarin) from the leaves Cynara cardunculus L. (Asteraceae) without the use any chromatographic steps is described. The procedure was based on separation of the fraction rich in 1,5-dicaffeoylquinic acid, isomerisation of 1,5-dicaffeoylquinic acid to cynarin and, owing to its higher polarity, the simple isolation of cynarin from the reaction mixture. Cynarin inhibited HIV-1 replication in MT-2 cell culture at nontoxic concentrations similar to other previously tested dicaffeoylquinic acids, which have been recently established as a potent and highly selective class of HIV-1 integrase inhibitors. ER -
SLANINA, Jiří, Eva TÁBORSKÁ, Hana BOCHOŘÁKOVÁ, Iva SLANINOVÁ, Otakar HUMPA, W. Edward ROBINSON and Karl H. SCHRAM. New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid. \textit{Tetrahedron Letters}. Oxford: Pergamon - Elsevier Science, 2001, vol.~42, No~19, p.~3383-6767. ISSN~0040-4039.
|