| SLANINA, Jiří, Eva TÁBORSKÁ, Hana BOCHOŘÁKOVÁ, Iva SLANINOVÁ, Otakar HUMPA, W. Edward ROBINSON and Karl H. SCHRAM. New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid. Tetrahedron Letters. Oxford: Pergamon - Elsevier Science, 2001, vol. 42, No 19, p. 3383-6767. ISSN 0040-4039. |
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@article{365191,
author = {Slanina, Jiří and Táborská, Eva and Bochořáková, Hana and Slaninová, Iva and Humpa, Otakar and Robinson, W. Edward and Schram, Karl H.},
article_location = {Oxford},
article_number = {19},
keywords = {Antivirals; biologically active compounds; isomerisation; phenolics; tannins},
language = {eng},
issn = {0040-4039},
journal = {Tetrahedron Letters},
title = {New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid},
volume = {42},
year = {2001}
}
TY - JOUR
ID - 365191
AU - Slanina, Jiří - Táborská, Eva - Bochořáková, Hana - Slaninová, Iva - Humpa, Otakar - Robinson, W. Edward - Schram, Karl H.
PY - 2001
TI - New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid
JF - Tetrahedron Letters
VL - 42
IS - 19
SP - 3383
EP - 3383
PB - Pergamon - Elsevier Science
SN - 00404039
KW - Antivirals
KW - biologically active compounds
KW - isomerisation
KW - phenolics
KW - tannins
N2 - A facile and inexpensive preparation of 1,3-dicaffeoylquinic acid (cynarin) from the leaves Cynara cardunculus L. (Asteraceae) without the use any chromatographic steps is described. The procedure was based on separation of the fraction rich in 1,5-dicaffeoylquinic acid, isomerisation of 1,5-dicaffeoylquinic acid to cynarin and, owing to its higher polarity, the simple isolation of cynarin from the reaction mixture. Cynarin inhibited HIV-1 replication in MT-2 cell culture at nontoxic concentrations similar to other previously tested dicaffeoylquinic acids, which have been recently established as a potent and highly selective class of HIV-1 integrase inhibitors.
ER -
SLANINA, Jiří, Eva TÁBORSKÁ, Hana BOCHOŘÁKOVÁ, Iva SLANINOVÁ, Otakar HUMPA, W. Edward ROBINSON and Karl H. SCHRAM. New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid. \textit{Tetrahedron Letters}. Oxford: Pergamon - Elsevier Science, 2001, vol.~42, No~19, p.~3383-6767. ISSN~0040-4039.
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