MALOŇ, M., J. ROLČÍK, K. DOLEŽAL, Jaromír MAREK and Z. TRÁVNÍČEK. Bio-active Cu(II), Pd(II) and Pt(II) complexes of 6-benzylaminopurine derivatives. In JOURNAL OF INORGANIC BIOCHEMISTRY. NEW YORK: ELSEVIER SCIENCE INC, 2001, p. 326. 86:(1). ISSN-0162-0134.
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Basic information
Original name Bio-active Cu(II), Pd(II) and Pt(II) complexes of 6-benzylaminopurine derivatives
Authors MALOŇ, M., J. ROLČÍK, K. DOLEŽAL, Jaromír MAREK and Z. TRÁVNÍČEK.
Edition NEW YORK, JOURNAL OF INORGANIC BIOCHEMISTRY, p. 326-326, 86:(1), 2001.
Publisher ELSEVIER SCIENCE INC
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 10402 Inorganic and nuclear chemistry
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14310/01:00004388
Organization unit Faculty of Science
ISBN ISSN-0162-0134
UT WoS 000170467300623
Changed by Changed by: doc. RNDr. Jaromír Marek, Ph.D., učo 1989. Changed: 13/9/2001 10:18.
Abstract
In the course of our research on transition metal complexes with anticancer activity,1 a series of mononuclear Cu(II), Pd(II) and Pt(II) complexes with selected 6-benzylaminopurine derivatives, namely 6-(2-hydroxybenzylamino)purine 2OHBAP, 6-(3-fluorobenzylamino)purine 3FBAP, 2-(3-hydroxypropylamino)-6-benzylamino-9-isopropylpurine BOH and 2-(2-hydroxyethylamino)-6-benzylamino-9-metylpurine OLO, has been synthesized and characterized by elemental analysis, electronic, infrared and mass (FAB+, ESI+) spectral data, magnetic susceptibility and molar conductivity data. On the basis of data resulting mainly from a single crystal X-ray analysis, a composition of the prepared complexes is following: [CuCl3(2OHBAP+)2]Cl.2H2O, [CuCl3(3FBAP+)2]Cl.H2O, [PdCl3(BOH+)].H2O, [PdCl3(OLO+)].H2O, [PtCl3(BOH+)].H2O, [PtCl3(OLO+)].H2O. Cytotoxic activity of the complexes as well as the starting compounds was determined by a calcein AM assay on various human tumor cell lines.
Links
GA203/00/0152, research and development projectName: Syntéza, studium a biologická aktivita komplexních sloučenin vybraných přechodných kovů s purinovými deriváty
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