DVOŘÁKOVÁ, Dana, Pavel KREJČÍ, Jiří MAYER, Jiří FAJKUS, Aleš HAMPL and Petr DVOŘÁK. Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells. British Journal of Haematology. Oxford: Blackwell Science Ltd, 2001, roč. 113, February, p. 832-835. ISSN 0007-1048.
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Basic information
Original name Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells
Authors DVOŘÁKOVÁ, Dana (203 Czech Republic), Pavel KREJČÍ (203 Czech Republic), Jiří MAYER (203 Czech Republic), Jiří FAJKUS (203 Czech Republic), Aleš HAMPL (203 Czech Republic) and Petr DVOŘÁK (203 Czech Republic, guarantor).
Edition British Journal of Haematology, Oxford, Blackwell Science Ltd, 2001, 0007-1048.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.815
RIV identification code RIV/00216224:14330/01:00004756
Organization unit Faculty of Informatics
Keywords in English fibroblast growth factor receptor 3; chronic myeloid leukaemia; stem cell transplantation; BCR/ABL; prognosis
Tags BCR/ABL, chronic myeloid leukaemia, prognosis, stem cell transplantation
Tags International impact, Reviewed
Changed by Changed by: prof. RNDr. Jiří Fajkus, CSc., učo 28574. Changed: 5/1/2007 15:39.
Abstract
Patients suffering from CML express high levels of FGFR3 mRNA in white blood cells (WBCs). After stem cell transplantation and reconstitution of haematopoiesis, the expression of FGFR3 decreased and was maintained at low levels that are typical of healthy individuals. FGFR3 expression became upregulated again in patients that had accelerated BCR/ABL rearrangement and underwent relapse of leukaemia.
Links
GA301/99/0045, research and development projectName: Dynamika telomer u vybraných typů solidních maligních onemocnění
Investor: Czech Science Foundation, Telomere dynamics in selected types of solid malignant diseases
IBS5004010, research and development projectName: Vývoj nových diagnostických technik pro onkologii
Investor: Academy of Sciences of the Czech Republic, Development of new diagnostic teniques for oncology
MSM 143100008, plan (intention)Name: Genomy a jejich funkce
Investor: Ministry of Education, Youth and Sports of the CR, Genomes and their functions
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