HADAŠOVÁ, Eva, Alexandra ŽOURKOVÁ and Olga ZELENKOVÁ. Dynamics of clinical response to paroxetine in coherence with CYP 2D6 metabolic status during long-term therapy of depressive disorder. In International Congress 2001: "Severe Debilitating diseases". Abstract Book. Johannesburg (JAR): Medunsa University (JAR), 2001, p. 89. sv. 1.
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Basic information
Original name Dynamics of clinical response to paroxetine in coherence with CYP 2D6 metabolic status during long-term therapy of depressive disorder
Authors HADAŠOVÁ, Eva, Alexandra ŽOURKOVÁ and Olga ZELENKOVÁ.
Edition Johannesburg (JAR), International Congress 2001: "Severe Debilitating diseases". Abstract Book. p. 89-89, sv. 1, 2001.
Publisher Medunsa University (JAR)
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 30104 Pharmacology and pharmacy
Country of publisher South Africa
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/01:00004764
Organization unit Faculty of Medicine
Keywords in English Pharmacogenetics; genetic polymorphism; cytochrome P 450 2D6; depressive disorder; adverse effects;
Tags adverse effects, cytochrome P 450 2D6, depressive disorder, genetic polymorphism, Pharmacogenetics
Changed by Changed by: prof. MUDr. Eva McCaskey Hadašová, CSc., učo 709. Changed: 28/11/2001 10:45.
Abstract
Adverese effects of the long-term therapy with SSRI antidepressants including sexual disorders may be more pronounced in patients with decreased activity of CYP 2D6, either given by the defect of the enzyme expression or evoked by previous treatment with enzyme inhibitors.
Links
NF6159, research and development projectName: Dynamika fenotypu CYP 2D6 u pacientů léčených paroxetinem ve vztahu ke klinickým korelátům.
Investor: Ministry of Health of the CR, Phenotype dynamics in patient treated by paroxetine regarding the clinical correlates
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