Dynamics of clinical response to paroxetine in coherence with CYP 2D6 metabolic status during long-term therapy of depressive disorder.

HADAŠOVÁ, Eva, Alexandra ŽOURKOVÁ and Olga ZELENKOVÁ. Dynamics of clinical response to paroxetine in coherence with CYP 2D6 metabolic status during long-term therapy of depressive disorder. South African Journal of Science. Johannesburg, 2001, vol. 55, No 6, p. 193.

Basic information

• Original name: Dynamics of clinical response to paroxetine in coherence with CYP 2D6 metabolic status during long-term therapy of depressive disorder.
• Authors: HADAŠOVÁ, Eva, Alexandra ŽOURKOVÁ and Olga ZELENKOVÁ.
• Edition: South African Journal of Science, Johannesburg, 2001.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: South Africa
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/01:00004765
• Organization unit: Faculty of Medicine
• Keywords in English: Genetic polymorphism; cytochrome P450; SSRI; psychiatry; sexual disorder
• Tags: cytochrome P450, genetic polymorphism, psychiatry, sexual disorder, SSRI

Abstract

Long-term therapy with SSRI antidepressants can evoke adverse effects including sexual disorders which may be more pronounced in patients with decreased activity of CYP 2D6, either given by the defect of the enzyme expression or evoked by previous treatment with enzyme inhibitors.

Links

• NF6159, research and development project: Name: Dynamika fenotypu CYP 2D6 u pacientů léčených paroxetinem ve vztahu ke klinickým korelátům.

Investor: Ministry of Health of the CR, Phenotype dynamics in patient treated by paroxetine regarding the clinical correlates