J 2001

Dynamics of clinical response to paroxetine in coherence with CYP 2D6 metabolic status during long-term therapy of depressive disorder.

HADAŠOVÁ, Eva, Alexandra ŽOURKOVÁ and Olga ZELENKOVÁ

Basic information

Original name

Dynamics of clinical response to paroxetine in coherence with CYP 2D6 metabolic status during long-term therapy of depressive disorder.

Authors

HADAŠOVÁ, Eva, Alexandra ŽOURKOVÁ and Olga ZELENKOVÁ

Edition

South African Journal of Science, Johannesburg, 2001

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

South Africa

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/01:00004765

Organization unit

Faculty of Medicine

Keywords in English

Genetic polymorphism; cytochrome P450; SSRI; psychiatry; sexual disorder
Změněno: 28/11/2001 11:37, prof. MUDr. Eva McCaskey Hadašová, CSc.

Abstract

V originále

Long-term therapy with SSRI antidepressants can evoke adverse effects including sexual disorders which may be more pronounced in patients with decreased activity of CYP 2D6, either given by the defect of the enzyme expression or evoked by previous treatment with enzyme inhibitors.

Links

NF6159, research and development project
Name: Dynamika fenotypu CYP 2D6 u pacientů léčených paroxetinem ve vztahu ke klinickým korelátům.
Investor: Ministry of Health of the CR, Phenotype dynamics in patient treated by paroxetine regarding the clinical correlates