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@inproceedings{378866,
author = {Ševčíková, Sabina and Zahradníčková, Eva and Souček, Karel and Šmarda, Jan},
address = {Frederick, Maryland, USA},
booktitle = {The Seventeenth Annual Meeting on Oncogene},
keywords = {Myb; Fos; Jun; differentiation},
language = {eng},
location = {Frederick, Maryland, USA},
pages = {171-171},
publisher = {Foundation for Advanced Cancer Studies, Inc.},
title = {v-Jun and v-Fos proteins induce dedifferentiation of v-myb-transformed monoblasts},
year = {2001}
}
TY - JOUR
ID - 378866
AU - Ševčíková, Sabina - Zahradníčková, Eva - Souček, Karel - Šmarda, Jan
PY - 2001
TI - v-Jun and v-Fos proteins induce dedifferentiation of v-myb-transformed monoblasts
PB - Foundation for Advanced Cancer Studies, Inc.
CY - Frederick, Maryland, USA
KW - Myb
KW - Fos
KW - Jun
KW - differentiation
N2 - The fos/jun proto-oncogenes encode for proteins which are components of the AP-1 transcription complex that includes several Fos related and Jun related proteins. The AP-1 was shown to play multiple roles in functional development of hematopoietic precursor cells into mature blood cells. Proto-oncogenes of the fos/jun family are considered to be positive regulators of myeloid differentiation. Enforced c-fos and c-jun expression in certain myeloid leukemia cell lines results in increased propensity to differentiate. The line of v-Myb-transformed chicken monoblasts (BM2) can be induced to differentiate phorbol esters. Differentiation-promoting effects of 12-O-tetradecanoyl phorbol 13-acetate (TPA) on BM2 cells is carried though activation of protein kinase C followed by changes of activities of differentiation and proliferation regulators, including AP-1. To gain further insights into the role of fos/jun in leukemogenicity, BM2vJUN and BM2vFOS cell lines, which inducibly express v-jun and v-fos, respectively, were established. We found that either v-fos- or v-jun-expressing BM2 cells exhibit signs of dedifferentiation. They decrease ability to reduce NBT and increase expression of differentiation-specific markers as Mo-1 and MEP-17. This suggests that oncogenic forms of Jun and Fos proteins can further enforce v-Myb transformation.
ER -
ŠEVČÍKOVÁ, Sabina, Eva ZAHRADNÍČKOVÁ, Karel SOUČEK and Jan ŠMARDA. v-Jun and v-Fos proteins induce dedifferentiation of v-myb-transformed monoblasts. In \textit{The Seventeenth Annual Meeting on Oncogene}. Frederick, Maryland, USA: Foundation for Advanced Cancer Studies, Inc., 2001, p.~171.
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