Vliv metamfetaminu na aktivitu P-450 na modelu perfundovaných jater u potkanů Wistar albino

SLÍVA, Jiří, Pavlína ZHARFBINOVÁ and Eva HADAŠOVÁ. Vliv metamfetaminu na aktivitu P-450 na modelu perfundovaných jater u potkanů Wistar albino (Influence of methamphetamine on the activity of P-450 in the perfused liver of Wistar albino rats). In In Kongres MEFA 2001; Sborník abstrakt. Brno: BVV Veletrhy Brno, 2001, p. 61-62. sv. 1.

Basic information

• Original name: Vliv metamfetaminu na aktivitu P-450 na modelu perfundovaných jater u potkanů Wistar albino
• Name (in English): Influence of methamphetamine on the activity of P-450 in the perfused liver of Wistar albino rats
• Authors: SLÍVA, Jiří, Pavlína ZHARFBINOVÁ and Eva HADAŠOVÁ.
• Edition: Brno, In Kongres MEFA 2001; Sborník abstrakt, p. 61-62, sv. 1, 2001.
• Publisher: BVV Veletrhy Brno

Other information

• Original language: Czech
• Type of outcome: Proceedings paper
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/01:00004886
• Organization unit: Faculty of Medicine
• Keywords in English: methamphetamine; cytochrome P-450; isolated liver; rat
• Tags: cytochrome P-450, isolated liver, methamphetamine, rat

Abstract

Byl studován vliv metamfetaminu (MET) na aktivitu enzymů CYP 2D a 3A v izolovaných perfundovaných játrech potkana. Bylo zjištěno, že 10-denní aplikace MET signifikantně zvyšuje aktivitu CYP 2D i CYP 3A. Přímý vliv na aktivitu těchto enzymů po aplikaci MET do perfuzního roztoku prokázán nebyl.

Abstract (in English)

The study was focused on the influence of methamphetamine (MET)on the activities of CYP 2D and 3A in the isolated perfused rat liver. The results showed that MET significantly increased the activity of both CYP isozymes after 10 days of premedication probably by the indirect mechanism, because it did not influence their activity when administered directly into the perfusion solution.