Metal complexes as anticancer agents 2. Iron(III) and copper(II) bio-active complexes with N-6-benzylaminopurine derivatives

MALOŇ, M., Z. TRÁVNÍČEK, M. MARYŠKO, R. ZBOŘIL, M. MAŠLÁŇ, Jaromír MAREK, K. DOLEŽAL, J. ROLČÍK, V. KRYŠTOF and M. STRNAD. Metal complexes as anticancer agents 2. Iron(III) and copper(II) bio-active complexes with N-6-benzylaminopurine derivatives. Inorganica Chimica Acta. Oxford, UK: Elsevier Science, 2001, vol. 323, 1-2, p. 119-129. ISSN 0020-1693.

Basic information

• Original name: Metal complexes as anticancer agents 2. Iron(III) and copper(II) bio-active complexes with N-6-benzylaminopurine derivatives
• Authors: MALOŇ, M., Z. TRÁVNÍČEK, M. MARYŠKO, R. ZBOŘIL, M. MAŠLÁŇ, Jaromír MAREK, K. DOLEŽAL, J. ROLČÍK, V. KRYŠTOF and M. STRNAD.
• Edition: Inorganica Chimica Acta, Oxford, UK, Elsevier Science, 2001, 0020-1693.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10402 Inorganic and nuclear chemistry
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 1.394
• RIV identification code: RIV/00216224:14310/01:00004987
• Organization unit: Faculty of Science
• UT WoS: 000172077100015
• Keywords in English: ron(III) and copper(II) complexes; 6-benzylaminopurine derivatives; cytotoxic activity; CDK inhibitor; magnetic properties; crystal structures
• Tags: 6-benzylaminopurine derivatives, CDK inhibitor, crystal structures, cytotoxic activity, magnetic properties, ron(III) and copper(II) complexes

Abstract

Iron(III) complexes with 2-(3-hydroxypropylamino)-6-benzylaniino-9-isopropylpurine (Bohemin, HL1), in its protonized form, of the composition (H+HL1)(2)[FeCl5]. 2H(2)O (1), (H+HL1)(2)[FeCl5]. 3H(2)O (2) have been prepared by two different routes. A new way for synthesis of copper(II) complex with 6-(2-chlorobenzylamino)purine (HL2), [Cu-2(mu -Cl)(2)(mu -HL2)(2)(HL2)(2)Cl-2]. 2H(2)O (3), together with the preparation of copper(II) complex with 6-(3-chlorobenzylamino)purine (HL3), [Cu-2(mu -Cl)(2)(mu -HL3)(2)Cl-2] (4), is also reported. The characterization have been based on elemental analysis, electronic, infrared, ES + mass and Fe-57 Mossbauer spectra, conductivity data and magnetic susceptibility temperature measurements over the 4.5-300 K for 1-3, and 35-300 K for 4. temperature range, respectively. Molecular structure of an electroneutral form of the HL2 ligand, (HL2. 2H(2)O), and a protonized form of the HL3 ligand, (H+HL3-Cl), have been determined by a single-crystal X-ray analysis. A mononuclear trigonal-bipyramidal (for 1 and 2), binuclear octahedral (for 3) and binuclear trigonal-bipyramidal (for 4) structures of the complexes were proposed mainly on the basis of spectral and magnetic properties. An S = 3/2-5/2 spin-admixed state in 1 and 2 was found to be related to the presence of [FeCl5](2-) (S = 3/2) and [FeCl5(H2O)](2-) (S = 5/2) complex anions in I and 2, as found by Fe-57 Mossbauer spectroscopy. Cytotoxic activity of the complexes was determined by a calcein AM assay and IC50 values were also estimated. For testing, human malignant melanoma cell line G-361. human osteogenic sarcoma cell line HOS, human chronic myelogenous leukaemia K-562 and human breast adenocarcinoma cell line MCF7 were used. The inhibition of p34(cdc2) kinase by the complexes I and 2, which is known to be one of the important mechanisms responsible for cytotoxicity of cytokinin-derived compounds, was also studied.

Links

• GA203/00/0152, research and development project: Name: Syntéza, studium a biologická aktivita komplexních sloučenin vybraných přechodných kovů s purinovými deriváty
• MSM 143100008, plan (intention): Name: Genomy a jejich funkce

Investor: Ministry of Education, Youth and Sports of the CR, Genomes and their functions