ŠERÝ, Omar, Veronika VOJTOVÁ and Petr ZVOLSKÝ. The Association Study of DRD2, ACE and AGT Gene Polymorphisms and Metamphetamine Dependence. Physiological Research. Czech Republic: Academy of Sciences of the Czech Rep., 2001, vol. 50, No 1, p. 43-50. ISSN 0862-8408.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name The Association Study of DRD2, ACE and AGT Gene Polymorphisms and Metamphetamine Dependence
Authors ŠERÝ, Omar (203 Czech Republic, guarantor), Veronika VOJTOVÁ (203 Czech Republic) and Petr ZVOLSKÝ.
Edition Physiological Research, Czech Republic, Academy of Sciences of the Czech Rep. 2001, 0862-8408.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.027
RIV identification code RIV/00216224:14310/01:00005069
Organization unit Faculty of Science
UT WoS 000167660100007
Keywords in English TaqI A polymorphism; DRD2; ACE; M235T; Angiotensinogen; Metamphetamine dependence
Tags ACE, angiotensinogen, DRD2, M235T, Metamphetamine dependence, TaqI A polymorphism
Tags International impact, Reviewed
Changed by Changed by: prof. RNDr. Omar Šerý, Ph.D., učo 18120. Changed: 1/3/2007 15:56.
Abstract
We investigated for the first time the association between the metamphetamine dependence and TaqI A polymorphism of the dopamine receptor D2 gene, I/D ACE polymorphism and M235T polymorphism of the angiotensinogen gene (AGT) in 93 unrelated metamphetamine dependent subjects and 131 controls. Our results did not prove any association of the TaqI A polymorphism of the DRD2 gene, I/D polymorphism of ACE gene and M235T polymorphism of AGT gene with the metamphetamine dependence in Caucasians of Czech origin, however, a statistically significant difference in I allele frequency between male control and female control groups for the I/D ACE polymorphism (p<0.03) was found.
Links
MSM 141100002, plan (intention)Name: Molekulární patofyziologie multigenních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases
NF5991, research and development projectName: Genetika závislostí: zjišťování vztahu polymorfizmů kandidátních genů k alkoholizmu
Investor: Ministry of Health of the CR, Genetic study of alcohol dependence : detection of the association between candidate gene polymorphisms and alcoholism.
NF6520, research and development projectName: Klinické a molekulárně-biologické koreláty hyperkinetické poruchy v dětském věku
Investor: Ministry of Health of the CR, Clinical and molecular-biological correlates of attention deficit hyperactivity disorder in children
PrintDisplayed: 11/9/2024 07:04