The Association Study of DRD2, ACE and AGT Gene Polymorphisms and Metamphetamine Dependence

ŠERÝ, Omar, Veronika VOJTOVÁ and Petr ZVOLSKÝ. The Association Study of DRD2, ACE and AGT Gene Polymorphisms and Metamphetamine Dependence. Physiological Research. Czech Republic: Academy of Sciences of the Czech Rep., 2001, vol. 50, No 1, p. 43-50. ISSN 0862-8408.

Basic information

Original name

The Association Study of DRD2, ACE and AGT Gene Polymorphisms and Metamphetamine Dependence

Authors

ŠERÝ, Omar (203 Czech Republic, guarantor), Veronika VOJTOVÁ (203 Czech Republic) and Petr ZVOLSKÝ

Edition

Physiological Research, Czech Republic, Academy of Sciences of the Czech Rep. 2001, 0862-8408

---

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.027

RIV identification code

RIV/00216224:14310/01:00005069

Organization unit

Faculty of Science

UT WoS

000167660100007

Keywords in English

TaqI A polymorphism; DRD2; ACE; M235T; Angiotensinogen; Metamphetamine dependence

Tags

ACE, angiotensinogen, DRD2, M235T, Metamphetamine dependence, TaqI A polymorphism

Tags

International impact, Reviewed

---

Abstract

V originále

We investigated for the first time the association between the metamphetamine dependence and TaqI A polymorphism of the dopamine receptor D2 gene, I/D ACE polymorphism and M235T polymorphism of the angiotensinogen gene (AGT) in 93 unrelated metamphetamine dependent subjects and 131 controls. Our results did not prove any association of the TaqI A polymorphism of the DRD2 gene, I/D polymorphism of ACE gene and M235T polymorphism of AGT gene with the metamphetamine dependence in Caucasians of Czech origin, however, a statistically significant difference in I allele frequency between male control and female control groups for the I/D ACE polymorphism (p<0.03) was found.

---

Links

MSM 141100002, plan (intention)	Name: Molekulární patofyziologie multigenních chorob Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases
NF5991, research and development project	Name: Genetika závislostí: zjišťování vztahu polymorfizmů kandidátních genů k alkoholizmu Investor: Ministry of Health of the CR, Genetic study of alcohol dependence : detection of the association between candidate gene polymorphisms and alcoholism.
NF6520, research and development project	Name: Klinické a molekulárně-biologické koreláty hyperkinetické poruchy v dětském věku Investor: Ministry of Health of the CR, Clinical and molecular-biological correlates of attention deficit hyperactivity disorder in children