Effect of modulation of ionic channel conductivities on restitution processes in cardiac cells (Computer modelling).

PÁSEK, Michal and Jiří ŠLICHTA. Effect of modulation of ionic channel conductivities on restitution processes in cardiac cells (Computer modelling). In Mechatronics robotics and biomechanics. Třešť: Institute of Solid Mechanics, Faculty of Mechanical Engineering, 2001, p. 235-236. ISBN 80-7204-207-6.

Basic information

Original name

Effect of modulation of ionic channel conductivities on restitution processes in cardiac cells (Computer modelling).

Authors

PÁSEK, Michal (203 Czech Republic, guarantor) and Jiří ŠLICHTA

Edition

Třešť, Mechatronics robotics and biomechanics, p. 235-236, 2001

Publisher

Institute of Solid Mechanics, Faculty of Mechanical Engineering

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Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

10610 Biophysics

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/01:00005118

Organization unit

Faculty of Medicine

ISBN

80-7204-207-6

Keywords in English

cardiac cell; electrical restitution

Tags

Cardiac cell, Electrical restitution

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Abstract

V originále

The restitution properties of cardiac action potential were shown to be important determinants of stability of reentrant arrhythmias. The restitution hypothesis states that steeply sloped restitution curves (relations between action potential duration and preceding diastolic interval) induce unstable wave propagation that results in wave break, the event that leads to fibrillation. In this contribution we try to explore the effect of modulation of membrane channel conductuvities on electrical restitution curves by means of computer modelling.