J 2001

Polymorphisms in angiotensinogen gene (M235T and G/-6/A) in multifactorial diseases.

VAŠKŮ, Anna, Lydie IZAKOVIČOVÁ HOLLÁ, Vladimír VAŠKŮ, Svatava TSCHÖPLOVÁ, Andrea STEJSKALOVÁ et. al.

Basic information

Original name

Polymorphisms in angiotensinogen gene (M235T and G/-6/A) in multifactorial diseases.

Authors

VAŠKŮ, Anna (203 Czech Republic, guarantor), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic), Vladimír VAŠKŮ (203 Czech Republic), Svatava TSCHÖPLOVÁ (203 Czech Republic) and Andrea STEJSKALOVÁ (203 Czech Republic)

Edition

Pathophysiology, Amsterdam (Netherlande), Elsevier, 2001, 0928-4680

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/01:00005187

Organization unit

Faculty of Medicine
Změněno: 24/4/2003 10:13, prof. MUDr. Anna Vašků, CSc.

Abstract

V originále

The aim of the study is to compare results of three association (case-control) studies in three multifactorial disorders (essential hypertension, atopic diseases and psoriasis) with two polymorphisms of angiotensinogen gene (M235T and A(-6)G AGT). The diseases were chosen for their multigenic base and different immunological characteristic (Th1, Th2 and Thps) and angiotensinogen gene for its pleiotropic functional effects in general adaptive reactions. In all (control as well as case) groups, tight linkage disequilibrium between the polymorphisms was found. The strength of linkage (%) differed among the group. The direction of the linkage is identical in all groups (T is combined with A, M is combined with G). In hypertensive-normotensive study, only Hardy-Weinberg disequilibria were found, especially in men. No case-control differences were found for either single alleles or for allelic concurrence of both polymorphisms. In atopy-control study, marginal case-control differences in single allele distribution of both polymorphisms were found, but only in women. In psoriasis-control study, the only significant case-control difference was found when genotypes MTAA and MTGG were present in 2/136 psoriatic patients vs. 20/142 control subjects (OR 0.1, 95% confidence interval 0.02-0.42, P=0.00015). The frequent polymorphisms in pleiotropic genes can form different formulae of genotype distribution in different multigenic diseases according to their contribution to the onset and/or progression of the disease in some evolutionary consequences.

Links

GA306/93/2192, research and development project
Name: Polymorfismy genů pro angiotensinogen a angiotensin I konvertasu u esenciální hypertense.
Investor: Czech Science Foundation, Polymorphisms of Genes Coding for Angiotensinogen and Angiotensin I Convertase in Essential Hypertension
GA306/96/0099, research and development project
Name: Polymorfismus genu pro endotelin - 1 (EDN 1) u esenciální hypertense
Investor: Czech Science Foundation, Polymorphism of endothelin - 1 gene (EDN 1) in essential hypertension
MSM 141100002, plan (intention)
Name: Molekulární patofyziologie multigenních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases