Detailed Information on Publication Record
2001
Deterministic modeling of the chromatin organization in human cell nuclei
VORÁČEK, Jan, Michal KOZUBEK, Eva BÁRTOVÁ and Markus MANNIOBasic information
Original name
Deterministic modeling of the chromatin organization in human cell nuclei
Authors
VORÁČEK, Jan, Michal KOZUBEK (203 Czech Republic), Eva BÁRTOVÁ (203 Czech Republic) and Markus MANNIO
Edition
Delft, Shaping future with simulation, p. 1-7, 2001
Publisher
TU Delft
Other information
Language
English
Type of outcome
Stať ve sborníku
Field of Study
20200 2.2 Electrical engineering, Electronic engineering, Information engineering
Country of publisher
Netherlands
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
RIV identification code
RIV/00216224:14330/01:00005225
Organization unit
Faculty of Informatics
ISBN
90-806441-1-0
Keywords in English
classification; chromosomes; fluorescence
Tags
International impact, Reviewed
Změněno: 7/5/2010 16:33, prof. RNDr. Michal Kozubek, Ph.D.
Abstract
V originále
Hitherto unpublished technique for prospective diagnostics of deleterious human diseases based on the generalization of the chromatin organization in human cell nuclei is introduced. Its principle is in the interaction with a model derived from image data, which are collected by the fully automated high resolution cytometer. The most significant topological descriptors of the cell nuclei are selected and processed in the inductive learning system. In its training phase the cytological properties of the analyzed cell as well as all the external stimuli are known and used for the proper adaptation. Then the resultant structure serves as a classifier categorizing unknown biological material in accordance with internal structure or parameters. Format of the input data and possible approaches to the problem formalization are presented and documented with several examples. Lastly, the experimental results are discussed and future research directions are suggested.
Links
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