D 2001

Deterministic modeling of the chromatin organization in human cell nuclei

VORÁČEK, Jan, Michal KOZUBEK, Eva BÁRTOVÁ and Markus MANNIO

Basic information

Original name

Deterministic modeling of the chromatin organization in human cell nuclei

Authors

VORÁČEK, Jan, Michal KOZUBEK (203 Czech Republic), Eva BÁRTOVÁ (203 Czech Republic) and Markus MANNIO

Edition

Delft, Shaping future with simulation, p. 1-7, 2001

Publisher

TU Delft

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

20200 2.2 Electrical engineering, Electronic engineering, Information engineering

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

abstract

RIV identification code

RIV/00216224:14330/01:00005225

Organization unit

Faculty of Informatics

ISBN

90-806441-1-0

Keywords in English

classification; chromosomes; fluorescence

Tags

chromosomes, CLASSIFICATION, fluorescence

Tags

International impact, Reviewed
Změněno: 7/5/2010 16:33, prof. RNDr. Michal Kozubek, Ph.D.

Abstract

V originále

Hitherto unpublished technique for prospective diagnostics of deleterious human diseases based on the generalization of the chromatin organization in human cell nuclei is introduced. Its principle is in the interaction with a model derived from image data, which are collected by the fully automated high resolution cytometer. The most significant topological descriptors of the cell nuclei are selected and processed in the inductive learning system. In its training phase the cytological properties of the analyzed cell as well as all the external stimuli are known and used for the proper adaptation. Then the resultant structure serves as a classifier categorizing unknown biological material in accordance with internal structure or parameters. Format of the input data and possible approaches to the problem formalization are presented and documented with several examples. Lastly, the experimental results are discussed and future research directions are suggested.

Links

MSM 143300002, plan (intention)
Name: Využití počítačové analýzy obrazu v optické mikroskopii
Investor: Ministry of Education, Youth and Sports of the CR, Application of computer image analysis in optical microscopy
Displayed: 12/11/2024 05:02