VORÁČEK, Jan, Michal KOZUBEK, Eva BÁRTOVÁ and Markus MANNIO. Deterministic modeling of the chromatin organization in human cell nuclei. In Shaping future with simulation. Delft: TU Delft, 2001, p. 1-7. ISBN 90-806441-1-0.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name Deterministic modeling of the chromatin organization in human cell nuclei
Authors VORÁČEK, Jan, Michal KOZUBEK (203 Czech Republic), Eva BÁRTOVÁ (203 Czech Republic) and Markus MANNIO.
Edition Delft, Shaping future with simulation, p. 1-7, 2001.
Publisher TU Delft
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 20200 2.2 Electrical engineering, Electronic engineering, Information engineering
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
WWW abstract
RIV identification code RIV/00216224:14330/01:00005225
Organization unit Faculty of Informatics
ISBN 90-806441-1-0
Keywords in English classification; chromosomes; fluorescence
Tags chromosomes, CLASSIFICATION, fluorescence
Tags International impact, Reviewed
Changed by Changed by: prof. RNDr. Michal Kozubek, Ph.D., učo 3740. Changed: 7/5/2010 16:33.
Abstract
Hitherto unpublished technique for prospective diagnostics of deleterious human diseases based on the generalization of the chromatin organization in human cell nuclei is introduced. Its principle is in the interaction with a model derived from image data, which are collected by the fully automated high resolution cytometer. The most significant topological descriptors of the cell nuclei are selected and processed in the inductive learning system. In its training phase the cytological properties of the analyzed cell as well as all the external stimuli are known and used for the proper adaptation. Then the resultant structure serves as a classifier categorizing unknown biological material in accordance with internal structure or parameters. Format of the input data and possible approaches to the problem formalization are presented and documented with several examples. Lastly, the experimental results are discussed and future research directions are suggested.
Links
MSM 143300002, plan (intention)Name: Využití počítačové analýzy obrazu v optické mikroskopii
Investor: Ministry of Education, Youth and Sports of the CR, Application of computer image analysis in optical microscopy
PrintDisplayed: 7/5/2024 05:43