VINKLEROVÁ, Jana and Alexandra ŠULCOVÁ. Endogenní kanabinoidy a jejich vliv na fagocytární aktivitu leukocytů u myší (Effect of endogenous cannabinoid receptor agonists on leukocyte phagocytosis in mice). Psychiatrie. Praha: Tigis, 2002, vol. 6, Suppl. 1, p. 44. ISSN 1211-7579.
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Basic information
Original name Endogenní kanabinoidy a jejich vliv na fagocytární aktivitu leukocytů u myší
Name (in English) Effect of endogenous cannabinoid receptor agonists on leukocyte phagocytosis in mice
Authors VINKLEROVÁ, Jana (203 Czech Republic, guarantor) and Alexandra ŠULCOVÁ (203 Czech Republic).
Edition Psychiatrie, Praha, Tigis, 2002, 1211-7579.
Other information
Original language Czech
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/02:00005252
Organization unit Faculty of Medicine
Keywords in English cannabinoid; anandamide; noladin; leukocyte phagocytosis; chemiluminescence; mice
Tags anandamide, cannabinoid, chemiluminescence, leukocyte phagocytosis, mice, noladin
Changed by Changed by: MUDr. Jana Unar Vinklerová, Ph.D., MBA, učo 2545. Changed: 18/1/2002 17:13.
Abstract
Ovlivňování imunitních funkcí je jedním z farmakodynamických účinků kanabinoidů. Sledovali jsme vliv endogeního agonisty kanabinoidních receptorů anandamidu (0.01; 1 a 10 mg/kg; i. p.) a nově objeveného endokanabinoidu noladinu (1 a 15 mg/kg; i. p.)na fagocytární aktivitu leukocytů u myší. Chemiluminometrickou metodou jsme u obou látek prokázali bifázický efekt působení a to, stimulace fagocytozy po nejnižších dávkách a její supresi po dávkách vyšších.
Abstract (in English)
The present study investigated the influence of endogenous cannabinoid receptor agonists anandamid (0.01; 1 and 10 mg/kg; i. p.) and noladin (1 and 15 mg/kg; i. p.) on immune function of leukocyte. Phagocytic activity of mouse leukocytes was measured in chemiluminescence (CL) assay using zymosan induction of phagocytosis and luminol potentiation of CL in vitro. Both agonists produced the increase of leukocyte phagocytic activity at the lower dose and decrease at the higher doses.
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