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@inproceedings{388651,
author = {Fojtová, Miloslava and Fulnečková, Jana and Fajkus, Jiří and Kovařík, Aleš},
address = {New York},
booktitle = {Journal of Biomolecular Structure and Dynamics},
keywords = {cadmium-induced apoptosis; tobacco},
language = {eng},
location = {New York},
pages = {963-963},
publisher = {Adenine Press},
title = {Reversibility of cadmium-induced apoptosis is associated with increased level of telomerase activity in tobacco TBY-2 cells},
year = {2001}
}
TY - JOUR
ID - 388651
AU - Fojtová, Miloslava - Fulnečková, Jana - Fajkus, Jiří - Kovařík, Aleš
PY - 2001
TI - Reversibility of cadmium-induced apoptosis is associated with increased level of telomerase activity in tobacco TBY-2 cells
PB - Adenine Press
CY - New York
KW - cadmium-induced apoptosis
KW - tobacco
N2 - To monitor apoptotic changes, we followed several parameters including cell viability, DNA integrity and telomerase activity.Preapoptotic phase has been achieved by exposure of cells to 50mM cadmium for 3 days.At that time the cell culture retains more than 95% viability although the majority of DNA is fragmented into 50-200 kb.Integrity of DNA is reestablished within two days after cadmium removal suggesting that an efficient DNA repair process has occurred.In parallel, a significant increase of telomerase activity in cell extracts is observed.The data suggest an involvement of telomerase in plant chromosome healing in response to damage caused by genotoxic agents.
ER -
FOJTOVÁ, Miloslava, Jana FULNEČKOVÁ, Jiří FAJKUS and Aleš KOVAŘÍK. Reversibility of cadmium-induced apoptosis is associated with increased level of telomerase activity in tobacco TBY-2 cells. In \textit{Journal of Biomolecular Structure and Dynamics}. New York: Adenine Press, 2001, p.~963. ISSN~0739-1102.
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