Detailed Information on Publication Record
2001
Reversibility of cadmium-induced apoptosis is associated with increased level of telomerase activity in tobacco TBY-2 cells
FOJTOVÁ, Miloslava, Jana FULNEČKOVÁ, Jiří FAJKUS and Aleš KOVAŘÍKBasic information
Original name
Reversibility of cadmium-induced apoptosis is associated with increased level of telomerase activity in tobacco TBY-2 cells
Authors
FOJTOVÁ, Miloslava, Jana FULNEČKOVÁ (203 Czech Republic), Jiří FAJKUS (203 Czech Republic, guarantor) and Aleš KOVAŘÍK (203 Czech Republic)
Edition
New York, Journal of Biomolecular Structure and Dynamics, p. 963-963, 2001
Publisher
Adenine Press
Other information
Language
English
Type of outcome
Stať ve sborníku
Field of Study
10610 Biophysics
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.243
RIV identification code
RIV/00216224:14310/01:00005257
Organization unit
Faculty of Science
ISSN
Keywords in English
cadmium-induced apoptosis; tobacco
Změněno: 24/6/2008 15:52, prof. RNDr. Jiří Fajkus, CSc.
Abstract
V originále
To monitor apoptotic changes, we followed several parameters including cell viability, DNA integrity and telomerase activity.Preapoptotic phase has been achieved by exposure of cells to 50mM cadmium for 3 days.At that time the cell culture retains more than 95% viability although the majority of DNA is fragmented into 50-200 kb.Integrity of DNA is reestablished within two days after cadmium removal suggesting that an efficient DNA repair process has occurred.In parallel, a significant increase of telomerase activity in cell extracts is observed.The data suggest an involvement of telomerase in plant chromosome healing in response to damage caused by genotoxic agents.
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