Detailed Information on Publication Record
2002
Polymorphism 4G/5G in the plasminogen activator inhibitor-1 (PAI-1) gene is associated with IgE-mediated allergic diseases and asthma in the Czech population
BUČKOVÁ, Dana, Lydie IZAKOVIČOVÁ HOLLÁ and Jiří VÁCHABasic information
Original name
Polymorphism 4G/5G in the plasminogen activator inhibitor-1 (PAI-1) gene is associated with IgE-mediated allergic diseases and asthma in the Czech population
Authors
BUČKOVÁ, Dana (203 Czech Republic, guarantor), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic) and Jiří VÁCHA (203 Czech Republic)
Edition
Allergy, Denmark, Munksgaard International Publishers, 2002, 0105-4538
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
Genetics and molecular biology
Country of publisher
Denmark
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 3.666
RIV identification code
RIV/00216224:14110/02:00005377
Organization unit
Faculty of Medicine
UT WoS
000175424400013
Keywords in English
allergic diseases; asthma; polymorphism; gene; PAI-1
Tags
Změněno: 17/6/2009 12:41, prof. MUDr. Lydie Izakovičová Hollá, Ph.D.
Abstract
V originále
Plasminogen activator inhibitor type 1 (PAI-1) is a glycoprotein that belongs to the serine protease inhibitor superfamily and has an essential role in tissue remodeling after inflammation. Recently, a single base pair deletion/insertion (4G/5G) polymorphism of the PAI-1 gene has been associated with an increased risk of asthma in nuclear families from the United Kingdom. Our findings support the idea that the 4G allele of the 4G/5G polymorphism in the PAI-1 gene may be a risk factor for IgE-mediated asthma and allergic diseases also in our Czech population.
Links
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