Use of S-Mosher acid as a chiral solvating agent for enantiomeric analysis of some trans-4-(4-fluorophenyl)-3-substituted-1-methylpiperidines by means of NMR spectroscopy

NAVRÁTILOVÁ, Hana. Use of S-Mosher acid as a chiral solvating agent for enantiomeric analysis of some trans-4-(4-fluorophenyl)-3-substituted-1-methylpiperidines by means of NMR spectroscopy. Chirality. USA: Willey-Liss, 2001, vol. 13, No 10, p. 731-735. ISSN 0899-0042.

Basic information

Original name

Use of S-Mosher acid as a chiral solvating agent for enantiomeric analysis of some trans-4-(4-fluorophenyl)-3-substituted-1-methylpiperidines by means of NMR spectroscopy

Authors

NAVRÁTILOVÁ, Hana

Edition

Chirality, USA, Willey-Liss, 2001, 0899-0042

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10401 Organic chemistry

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.554

RIV identification code

RIV/00216224:14330/01:00005424

Organization unit

Faculty of Informatics

UT WoS

000172005600024

Keywords in English

spectral non-equivalence; piperidines; NMR; paroxetine

Tags

NMR, paroxetine, piperidines, spectral non-equivalence

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Abstract

V originále

S-Mosher acid induced chemical-shift non-equivalence in NMR spectra of chiral trans-4-(4-fluorophenyl)-3-substituted-1-methylpiperidines. The magnitude of Dd in 1H and 19F NMR spectra varied with the substituent at position 3 of the piperidine ring. The magnitudes Dd observed for certain protons and for the fluorine in the 4-fluorophenyl group were sufficiently large to allow determination of enantiomeric composition.

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Links

MSM 143100011, plan (intention)

Name: Struktura a vazebné poměry, vlastnosti a analýza syntetických a přírodních molekulových ansamblů Investor: Ministry of Education, Youth and Sports of the CR, Structure and character of bonding, properties and analysis of synthetic and natural molecular ensembles