NAVRÁTILOVÁ, Hana. Enantiomeric analysis of (3S,4R)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine by 19F NMR spectroscopy. Magnetic Resonance in Chemistry. Great Britain: Willey and Sons, Ltd., 2001, vol. 39, No 11, p. 727-730. ISSN 0749-1581. |
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@article{390996, author = {Navrátilová, Hana}, article_location = {Great Britain}, article_number = {11}, keywords = {NMR; 13C satellites; chemical-shift anisochrony; piperidines; paroxetine;}, language = {eng}, issn = {0749-1581}, journal = {Magnetic Resonance in Chemistry}, title = {Enantiomeric analysis of (3S,4R)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine by 19F NMR spectroscopy}, volume = {39}, year = {2001} }
TY - JOUR ID - 390996 AU - Navrátilová, Hana PY - 2001 TI - Enantiomeric analysis of (3S,4R)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine by 19F NMR spectroscopy JF - Magnetic Resonance in Chemistry VL - 39 IS - 11 SP - 727 EP - 727 PB - Willey and Sons, Ltd. SN - 07491581 KW - NMR KW - 13C satellites KW - chemical-shift anisochrony KW - piperidines KW - paroxetine; N2 - The chemical shift anisochrony of the fluorine signal for the enantiomerically enriched (3S,4R)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine was induced in the presence of S-Mosher acid and its magnitude varied with the enantiomeric purity of 1a. Very low quantities of an enantiomeric impurity 1b, ranging typically from 0.2 to 1%, were evaluated by comparing peak areas of 1b with those of 13C satellite signals that were deconvoluted using an automatic Lorentzian line fitting. ER -
NAVRÁTILOVÁ, Hana. Enantiomeric analysis of (3S,4R)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine by 19F NMR spectroscopy. \textit{Magnetic Resonance in Chemistry}. Great Britain: Willey and Sons, Ltd., 2001, vol.~39, No~11, p.~727-730. ISSN~0749-1581.
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