IZAKOVIČOVÁ HOLLÁ, Lydie, Dana BUČKOVÁ, Antonín FASSMANN, Petr BENEŠ and Vladimír ZNOJIL. Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers. Genes Immun. United Kingdom: Nature Publishing Group, 2002, vol. 3, No 5, p. 292-294. ISSN 1466-4879. |
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@article{395771, author = {Izakovičová Hollá, Lydie and Bučková, Dana and Fassmann, Antonín and Beneš, Petr and Znojil, Vladimír}, article_location = {United Kingdom}, article_number = {5}, keywords = {gene; polymorphism; PAI-1; periodontitis}, language = {eng}, issn = {1466-4879}, journal = {Genes Immun}, title = {Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers}, volume = {3}, year = {2002} }
TY - JOUR ID - 395771 AU - Izakovičová Hollá, Lydie - Bučková, Dana - Fassmann, Antonín - Beneš, Petr - Znojil, Vladimír PY - 2002 TI - Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers JF - Genes Immun VL - 3 IS - 5 SP - 292 EP - 292 PB - Nature Publishing Group SN - 14664879 KW - gene KW - polymorphism KW - PAI-1 KW - periodontitis N2 - Periodontal diseases belong to the most common chronic disorders affecting mankind. Smoking and impaired plasminogen activation with hypercoagulation and fibrinolysis inhibition have been proposed as having a role in predisposition to these diseases We investigated relationships among adult periodontitis, smoking and a variation in the deletion/insertion (4G/5G) promoter polymorphism of the plasminogen-activator-inhibitor-1 (PAI-1) gene in 304 Caucasian subjects. An association was detected between the deletion (4G) allele (and 4G/4G genotype) and periodontitis (p=0.0022, Pcorr.LT.0.01, p=0.014, Pcorr.LT.0.05). Even a stronger association occurred in non-smokers (p=0.00021, Pcorr.LT.0.01, p=0.0024, Pcorr.LT.0.05) where the presence of the PAI-1 gene 4G allele appears to be one of the risk factors for periodontitis. ER -
IZAKOVIČOVÁ HOLLÁ, Lydie, Dana BUČKOVÁ, Antonín FASSMANN, Petr BENEŠ and Vladimír ZNOJIL. Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers. \textit{Genes Immun}. United Kingdom: Nature Publishing Group, 2002, vol.~3, No~5, p.~292-294. ISSN~1466-4879.
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