Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a
Risk Factor for Adult Periodontitis in Non-Smokers

J 2002

Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers

IZAKOVIČOVÁ HOLLÁ, Lydie, Dana BUČKOVÁ, Antonín FASSMANN, Petr BENEŠ, Vladimír ZNOJIL et. al.

Basic information

Original name

Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers

Authors

IZAKOVIČOVÁ HOLLÁ, Lydie (203 Czech Republic, guarantor), Dana BUČKOVÁ (203 Czech Republic), Antonín FASSMANN (203 Czech Republic), Petr BENEŠ (203 Czech Republic) and Vladimír ZNOJIL (203 Czech Republic)

Edition

Genes Immun, United Kingdom, Nature Publishing Group, 2002, 1466-4879

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.060

RIV identification code

RIV/00216224:14110/02:00005507

Organization unit

Faculty of Medicine

UT WoS

000177380000007

Keywords in English

gene; polymorphism; PAI-1; periodontitis

Abstract

V originále

Periodontal diseases belong to the most common chronic disorders affecting mankind. Smoking and impaired plasminogen activation with hypercoagulation and fibrinolysis inhibition have been proposed as having a role in predisposition to these diseases We investigated relationships among adult periodontitis, smoking and a variation in the deletion/insertion (4G/5G) promoter polymorphism of the plasminogen-activator-inhibitor-1 (PAI-1) gene in 304 Caucasian subjects. An association was detected between the deletion (4G) allele (and 4G/4G genotype) and periodontitis (p=0.0022, Pcorr.LT.0.01, p=0.014, Pcorr.LT.0.05). Even a stronger association occurred in non-smokers (p=0.00021, Pcorr.LT.0.01, p=0.0024, Pcorr.LT.0.05) where the presence of the PAI-1 gene 4G allele appears to be one of the risk factors for periodontitis.

Links

MSM 141100002, plan (intention)

Name: Molekulární patofyziologie multigenních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases

Citovat

IZAKOVIČOVÁ HOLLÁ, Lydie, Dana BUČKOVÁ, Antonín FASSMANN, Petr BENEŠ and Vladimír ZNOJIL. Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers. Genes Immun. United Kingdom: Nature Publishing Group, 2002, vol. 3, No 5, p. 292-294. ISSN 1466-4879.

@article{395771,
   author = {Izakovičová Hollá, Lydie and Bučková, Dana and Fassmann, Antonín and Beneš, Petr and Znojil, Vladimír},
   article_location = {United Kingdom},
   article_number = {5},
   keywords = {gene; polymorphism; PAI-1; periodontitis},
   language = {eng},
   issn = {1466-4879},
   journal = {Genes Immun},
   title = {Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers},
   volume = {3},
   year = {2002}
}

TY  - JOUR
ID  - 395771
AU  - Izakovičová Hollá, Lydie - Bučková, Dana - Fassmann, Antonín - Beneš, Petr - Znojil, Vladimír
PY  - 2002
TI  - Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers
JF  - Genes Immun
VL  - 3
IS  - 5
SP  - 292
EP  - 292
PB  - Nature Publishing Group
SN  - 14664879
KW  - gene
KW  - polymorphism
KW  - PAI-1
KW  - periodontitis
N2  - Periodontal diseases belong to the most common chronic disorders affecting mankind. Smoking and impaired plasminogen activation with hypercoagulation and fibrinolysis inhibition have been proposed as having a role in predisposition to these diseases We investigated relationships among adult periodontitis, smoking and a variation in the deletion/insertion (4G/5G) promoter polymorphism of the plasminogen-activator-inhibitor-1 (PAI-1) gene in 304 Caucasian subjects. An association was detected between the deletion (4G) allele (and 4G/4G genotype) and periodontitis (p=0.0022, Pcorr.LT.0.01, p=0.014, Pcorr.LT.0.05). Even a stronger association occurred in non-smokers (p=0.00021, Pcorr.LT.0.01, p=0.0024, Pcorr.LT.0.05) where the presence of the PAI-1 gene 4G allele appears to be one of the risk factors for periodontitis.
ER  -

IZAKOVIČOVÁ HOLLÁ, Lydie, Dana BUČKOVÁ, Antonín FASSMANN, Petr BENEŠ and Vladimír ZNOJIL. Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers. \textit{Genes Immun}. United Kingdom: Nature Publishing Group, 2002, vol.~3, No~5, p.~292-294. ISSN~1466-4879.

Detailed Information on Publication Record