Polymorphism NcoI in tumor necrosis factor b is associated with
fasting glycemia and lipid parameters in healthy non-obese
Caucasian subjects: Preliminary report

J 2002

Polymorphism NcoI in tumor necrosis factor b is associated with fasting glycemia and lipid parameters in healthy non-obese Caucasian subjects: Preliminary report

KAŇKOVÁ, Kateřina; Ivana MÁROVÁ; Eugene HJM JANSEN; Anna VAŠKŮ; Michal JURAJDA et. al.

Basic information

Original name

Polymorphism NcoI in tumor necrosis factor b is associated with fasting glycemia and lipid parameters in healthy non-obese Caucasian subjects: Preliminary report

Name in Czech

Polymorfizmus NcoI v genu pro tumornekrotizujici faktor b je asociovan s glykemii nalacno a lipidovymi parametry u zdravych neobeznich osob: predbezne vysledky

Authors

KAŇKOVÁ, Kateřina; Ivana MÁROVÁ; Eugene HJM JANSEN; Anna VAŠKŮ; Michal JURAJDA and Jiří VÁCHA

Edition

Diabetes & Metabolism, Francie, Editions Masson, 2002, 0338-1684

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

30202 Endocrinology and metabolism

Country of publisher

France

Confidentiality degree

is not subject to a state or trade secret

Impact factor

Impact factor: 1.546 in 2001

RIV identification code

RIV/00216224:14110/02:00005552

Organization unit

Faculty of Medicine

UT WoS

000176985000009

Keywords in English

Type 2 diabetes mellitus; TNF-b polymorphism; insulin resistance; glycemia; glucose intolerance

Abstract

ORIG CZ

In the original language

Background: The study was designed to investigate the associations among polymorphisms TNF-b NcoI and TNF-a -308G/A, plasma TNF-a levels and metabolic and anthropometric parameters related to insulin sensitivity in a set of 113 Caucasian subjects undergoing oral glucose tolerance test (oGTT). Methods: Genotypes were detected by PCR; BMI, WHR, glycemia during oGTT, fasting immunoreactive insulin, fasting C-peptide, HbA1c, total cholesterol, triglycerides, HDL, LDL and plasma TNF-a levels were measured in each subject. Results: Type 2 diabetes was diagnosed in 10 subjects, impaired glucose tolerance (IGT) in 41, normal glucose tolerance (NGT) in 62. Significant differences among genotypes of the TNF-b NcoI were observed for FPG (P=0.0063), LDL (P=0.0179) and marginally for total cholesterol (P=0.0763) in NGT group. After the classification of NGT subjects into obese and non-obese according to BMI, associations of TNF-b NcoI with FPG, LDL and cholesterol were proved in non-obese subgroup only. TNF-a -308G/A polymorphism was not associated with any of the parameters studied. TNF-a levels did not revealed difference among NGT, IGT and DM groups or genotype-dependent differences. Conclusions: Our results indicate significant association of the TNF-b NcoI polymorphism with FPG, LDL and total cholesterol in normoglycemic non-obese Caucasian subjects. This polymorphism could be involved in genetic modulation of glucose and lipid homeostasis and regulation of insulin sensitivity already in healthy state. Disturbances of this regulation could be component of pathogenesis of type 2 diabetes mellitus.

In Czech

Zjistili jsme, ze polymorfizmus NcoI v genu pro tumornekrotizujici faktor b je asociovan s glykemii nalacno a lipidovymi parametry (LDL a cholesterol) u zdravych neobeznich osob.

Links

MSM 141100002, plan (intention)

Name: Molekulární patofyziologie multigenních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases

Cite

KAŇKOVÁ, Kateřina; Ivana MÁROVÁ; Eugene HJM JANSEN; Anna VAŠKŮ; Michal JURAJDA and Jiří VÁCHA. Polymorphism NcoI in tumor necrosis factor b is associated with fasting glycemia and lipid parameters in healthy non-obese Caucasian subjects: Preliminary report. Diabetes & Metabolism. Francie: Editions Masson, 2002, vol. 28, No 3, p. 231-237. ISSN 0338-1684.

@article{399632,
   author = {Kaňková, Kateřina and Márová, Ivana and Jansen, Eugene HJM and Vašků, Anna and Jurajda, Michal and Vácha, Jiří},
   article_location = {Francie},
   article_number = {3},
   keywords = {Type 2 diabetes mellitus; TNF-b polymorphism; insulin resistance; glycemia; glucose intolerance},
   language = {eng},
   issn = {0338-1684},
   journal = {Diabetes & Metabolism},
   title = {Polymorphism NcoI in tumor necrosis factor b is associated with fasting glycemia and lipid parameters in healthy non-obese Caucasian subjects: Preliminary report},
   volume = {28},
   year = {2002}
}

TY  - JOUR
ID  - 399632
AU  - Kaňková, Kateřina - Márová, Ivana - Jansen, Eugene HJM - Vašků, Anna - Jurajda, Michal - Vácha, Jiří
PY  - 2002
TI  - Polymorphism NcoI in tumor necrosis factor b is associated with fasting glycemia and lipid parameters in healthy non-obese Caucasian subjects: Preliminary report
JF  - Diabetes & Metabolism
VL  - 28
IS  - 3
SP  - 231
EP  - 231
PB  - Editions Masson
SN  - 03381684
KW  - Type 2 diabetes mellitus
KW  - TNF-b polymorphism
KW  - insulin resistance
KW  - glycemia
KW  - glucose intolerance
N2  - Background: The study was designed to investigate the associations among polymorphisms TNF-b NcoI and TNF-a -308G/A, plasma TNF-a levels and metabolic and anthropometric parameters related to insulin sensitivity in a set of 113 Caucasian subjects undergoing oral glucose tolerance test (oGTT). Methods: Genotypes were detected by PCR; BMI, WHR, glycemia during oGTT, fasting immunoreactive insulin, fasting C-peptide, HbA1c, total cholesterol, triglycerides, HDL, LDL and plasma TNF-a levels were measured in each subject. Results: Type 2 diabetes was diagnosed in 10 subjects, impaired glucose tolerance (IGT) in 41, normal glucose tolerance (NGT) in 62. Significant differences among genotypes of the TNF-b NcoI were observed for FPG (P=0.0063), LDL (P=0.0179) and marginally for total cholesterol (P=0.0763) in NGT group. After the classification of NGT subjects into obese and non-obese according to BMI, associations of TNF-b NcoI with FPG, LDL and cholesterol were proved in non-obese subgroup only. TNF-a -308G/A polymorphism was not associated with any of the parameters studied. TNF-a levels did not revealed difference among NGT, IGT and DM groups or genotype-dependent differences. Conclusions: Our results indicate significant association of the TNF-b NcoI polymorphism with FPG, LDL and total cholesterol in normoglycemic non-obese Caucasian subjects. This polymorphism could be involved in genetic modulation of glucose and lipid homeostasis and regulation of insulin sensitivity already in healthy state. Disturbances of this regulation could be component of pathogenesis of type 2 diabetes mellitus.
ER  -

KAŇKOVÁ, Kateřina; Ivana MÁROVÁ; Eugene HJM JANSEN; Anna VAŠKŮ; Michal JURAJDA and Jiří VÁCHA. Polymorphism NcoI in tumor necrosis factor b is associated with fasting glycemia and lipid parameters in healthy non-obese Caucasian subjects: Preliminary report. \textit{Diabetes \&{} Metabolism}. Francie: Editions Masson, 2002, vol.~28, No~3, p.~231-237. ISSN~0338-1684.

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