Detailed Information on Publication Record
2002
Polymorphism NcoI in tumor necrosis factor b is associated with fasting glycemia and lipid parameters in healthy non-obese Caucasian subjects: Preliminary report
KAŇKOVÁ, Kateřina, Ivana MÁROVÁ, Eugene HJM JANSEN, Anna VAŠKŮ, Michal JURAJDA et. al.Basic information
Original name
Polymorphism NcoI in tumor necrosis factor b is associated with fasting glycemia and lipid parameters in healthy non-obese Caucasian subjects: Preliminary report
Name in Czech
Polymorfizmus NcoI v genu pro tumornekrotizujici faktor b je asociovan s glykemii nalacno a lipidovymi parametry u zdravych neobeznich osob: predbezne vysledky
Authors
KAŇKOVÁ, Kateřina (203 Czech Republic, guarantor), Ivana MÁROVÁ (203 Czech Republic), Eugene HJM JANSEN (528 Netherlands), Anna VAŠKŮ (203 Czech Republic), Michal JURAJDA (203 Czech Republic) and Jiří VÁCHA (203 Czech Republic)
Edition
Diabetes & Metabolism, Francie, Editions Masson, 2002, 0338-1684
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30202 Endocrinology and metabolism
Country of publisher
France
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.546 in 2001
RIV identification code
RIV/00216224:14110/02:00005552
Organization unit
Faculty of Medicine
UT WoS
000176985000009
Keywords in English
Type 2 diabetes mellitus; TNF-b polymorphism; insulin resistance; glycemia; glucose intolerance
Tags
Změněno: 18/6/2009 09:51, prof. MUDr. Anna Vašků, CSc.
V originále
Background: The study was designed to investigate the associations among polymorphisms TNF-b NcoI and TNF-a -308G/A, plasma TNF-a levels and metabolic and anthropometric parameters related to insulin sensitivity in a set of 113 Caucasian subjects undergoing oral glucose tolerance test (oGTT). Methods: Genotypes were detected by PCR; BMI, WHR, glycemia during oGTT, fasting immunoreactive insulin, fasting C-peptide, HbA1c, total cholesterol, triglycerides, HDL, LDL and plasma TNF-a levels were measured in each subject. Results: Type 2 diabetes was diagnosed in 10 subjects, impaired glucose tolerance (IGT) in 41, normal glucose tolerance (NGT) in 62. Significant differences among genotypes of the TNF-b NcoI were observed for FPG (P=0.0063), LDL (P=0.0179) and marginally for total cholesterol (P=0.0763) in NGT group. After the classification of NGT subjects into obese and non-obese according to BMI, associations of TNF-b NcoI with FPG, LDL and cholesterol were proved in non-obese subgroup only. TNF-a -308G/A polymorphism was not associated with any of the parameters studied. TNF-a levels did not revealed difference among NGT, IGT and DM groups or genotype-dependent differences. Conclusions: Our results indicate significant association of the TNF-b NcoI polymorphism with FPG, LDL and total cholesterol in normoglycemic non-obese Caucasian subjects. This polymorphism could be involved in genetic modulation of glucose and lipid homeostasis and regulation of insulin sensitivity already in healthy state. Disturbances of this regulation could be component of pathogenesis of type 2 diabetes mellitus.
In Czech
Zjistili jsme, ze polymorfizmus NcoI v genu pro tumornekrotizujici faktor b je asociovan s glykemii nalacno a lipidovymi parametry (LDL a cholesterol) u zdravych neobeznich osob.
Links
MSM 141100002, plan (intention) |
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