Mechanismy přestavby chromatinu

ŠMARDOVÁ, Jana and Jan ŠMARDA. Mechanismy přestavby chromatinu (Mechanisms of chromatin remodeling). Biologické listy. Praha: Ústav molekulární genetiky AV ČR, vol. 66, No 4, p. 283-302. ISSN 0366-486. 2001.

Basic information

• Original name: Mechanismy přestavby chromatinu
• Name (in English): Mechanisms of chromatin remodeling
• Authors: ŠMARDOVÁ, Jana and Jan ŠMARDA.
• Edition: Biologické listy, Praha, Ústav molekulární genetiky AV ČR, 2001, 0366-486.

Other information

• Original language: Czech
• Type of outcome: Article in a journal
• Field of Study: Genetics and molecular biology
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14310/01:00005617
• Organization unit: Faculty of Science

Abstract

Chromatin je substrátem pro buněčné systémy zajišťující transkripci, replikaci, rekombinaci, reparaci DNA a segregaci chromozómů. Průběh těchto procesů závisí na přestavbách chromatinu, při kterých se zvyšuje přístupnost DNA pro určité proteiny. Přestavby chromatinu probíhají různými mechanismy, jejichž podstata je předmětem tohoto souborného článku.

Abstract (in English)

Chromatin appears to be ramarkably resistant to physical perturbation and inhospitable to molecular machines that use it as a substrate for transcription, replication, recombination, DNA repair and chromosome segregation. All of these processes are associated with chromatin remodeling increasing DNA accessibility to DNA-binding proteins. Several mechanisms have been identified that modelate chromatine structure: ATP-dependent chromatin remodeling complexes which work as machines to physically dissociate the DNA from histones and complex enzyme machinery chemically modifying histones. Histone post-translation modofications include acetylation, phosphorylation, methylation and ubiquitination, which usually take place on the tail domains of histones. Hisone modifications may alter chromatine structure by affecting histone-DNA interactions or may represent specific histone language - a "histone code" - encoded on the histone tail domains and read by other proteins or protein complexes. Chromatin remodeling is very complex process and its mechanisms are in focus of this review.

Links

• MSM 143100008, plan (intention): Name: Genomy a jejich funkce

Investor: Ministry of Education, Youth and Sports of the CR, Genomes and their functions