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@inproceedings{402212,
author = {Nováková, Marie and Bravený, Pavel},
address = {Oslo, Norway.},
booktitle = {1st Oslo Conference on Molecular Cardiology and Myocardial Function.},
keywords = {cardiac sigma receptor; arhythmogenesis; BD737},
language = {eng},
location = {Oslo, Norway.},
pages = {25-25},
title = {Arythmogenic effects of sigma agonist BD737},
year = {1999}
}
TY - JOUR
ID - 402212
AU - Nováková, Marie - Bravený, Pavel
PY - 1999
TI - Arythmogenic effects of sigma agonist BD737
CY - Oslo, Norway.
KW - cardiac sigma receptor
KW - arhythmogenesis
KW - BD737
N2 - Sigma receptor binding has been reported to alter contractility in isolated ventricular rat myocytes and to severely impair the regular rhythm in cell cultures. The aim of this study was to prove these effects of a highly selective sigma ligand BD737 in isolated perfused hearts. In contrast to isolated myocytes, the perfused whole hearts did not exhibit significant inotropic effects of 10nM BD737. However, the heart rate, steady at control conditions, revealed marked fluctuations, characteristic for IP3 production and [Ca2+]i oscillations measured in isolated myocytes. BD737 in 100nM concentration provoked bigeminy, multifocal ectopies and eventually, cardiac arrest. In conclusion, the perfused hearts are sensitive to sigma ligands in nanomolar concentrations, although the effects quantitavely differ from those on isolated myocytes.
ER -
NOVÁKOVÁ, Marie a Pavel BRAVENÝ. Arythmogenic effects of sigma agonist BD737. In \textit{1st Oslo Conference on Molecular Cardiology and Myocardial Function.}. Oslo, Norway., 1999, s.~25.
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