Detailed Information on Publication Record
2001
NAŠE ZKUŠENOSTI S INTRAARTERIÁLNI LOKOREGIONÁLNI CHEMOTERAPII METASTATICKÉHO KOLOREKTÁLNÍHO KARCINOMU DO JATER
KISS, Igor, J MARKOVÁ, Jiří TOMÁŠEK, Rostislav VYZULA, Vlastimil VÁLEK et. al.Basic information
Original name
NAŠE ZKUŠENOSTI S INTRAARTERIÁLNI LOKOREGIONÁLNI CHEMOTERAPII METASTATICKÉHO KOLOREKTÁLNÍHO KARCINOMU DO JATER
Name (in English)
Our experience with intraarterial locoregional chemotherapy of colorectal carcinoma metastatizing into the liver
Authors
KISS, Igor, J MARKOVÁ, Jiří TOMÁŠEK, Rostislav VYZULA, Vlastimil VÁLEK, Jaroslav BOUDNÝ, Zdeněk KALA, Ivo HANKE, Tomáš OSTRÍŽEK and Jindřich LEYPOLD
Edition
Praha, 4 pp. Vnitřní lékařství 47(12), 2001
Publisher
ČLS JEP
Other information
Language
Czech
Type of outcome
Odborná kniha
Field of Study
30200 3.2 Clinical medicine
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
Organization unit
Faculty of Medicine
Keywords in English
Colorectal carcinoma-
Změněno: 14/4/2002 17:16, MUDr. Ivo Hanke, Ph.D.
Abstract
In English
: Locoregional chemotherapy is one of the possible ways of treatment of inoperable metastatic affection of the liver by colorectal carcinoma. The advantage of regional administration of the cytostatic is the possibility to achieve a higher local concentration of the cytostatic associated with a higher percentage of therapeutic responses. In our department we preferred combined locoregional intraarterial chemotherapy (5-fluorouracil/Mitmycin C/Doxorubicin) combined with systemic intravenous chemotherapy (5-fluorouracil/leukovirin). Locoregional cghemotherapy was administered in the majority as chemotherapy of series 2 or 3 with a very good tolerance. In 2/19 patients we observed marked diminution of liver metastases and subsequent operability and with a duration of complete response for 13 and 18 months. In 7/19 patients a partial therapeutic response was achieved. The total therapeutic response (complete and partial) was 47%. Locoregional chemotherapy attains a higher therapeutic response as compared with systemic chemotherapy and is associated with an acceptable toxicity.