| MOHAMED, Walid Fathalla, Jaromír MAREK and Pavel PAZDERA. SYNTHESIS of 4-AMINO-3-CYANO-2-MORPHOLINOQUINOLINE. Heterocyclic Communications. London: Freund Publishing House, 2002, vol. 2002, No 1, p. 79-82. ISSN 0793-0283. |
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@article{403457,
author = {Mohamed, Walid Fathalla and Marek, Jaromír and Pazdera, Pavel},
article_location = {London},
article_number = {1},
keywords = {regioselectivity; 4-amino-3-cyano-2-morpholinoquinoline; Thorpe-Ziegler cyclization; 3;1-benzothiazepine; thioureas; sulfur elemination},
language = {eng},
issn = {0793-0283},
journal = {Heterocyclic Communications},
title = {SYNTHESIS of 4-AMINO-3-CYANO-2-MORPHOLINOQUINOLINE},
volume = {2002},
year = {2002}
}
TY - JOUR
ID - 403457
AU - Mohamed, Walid Fathalla - Marek, Jaromír - Pazdera, Pavel
PY - 2002
TI - SYNTHESIS of 4-AMINO-3-CYANO-2-MORPHOLINOQUINOLINE
JF - Heterocyclic Communications
VL - 2002
IS - 1
SP - 79
EP - 79
PB - Freund Publishing House
SN - 07930283
KW - regioselectivity
KW - 4-amino-3-cyano-2-morpholinoquinoline
KW - Thorpe-Ziegler cyclization
KW - 3;1-benzothiazepine
KW - thioureas
KW - sulfur elemination
N2 - The 4-amino-3-cyano-2-morpholinoquinoline was obtained via intramolecular Thorpe-Ziegler cyclization of 4-cyano-N4-(2-cyanophenyl)morpholine-4-carboximido-thioate 3 to afford the intermediate 3,1-benzothiazepine 4. Compound 4 undergoes ring contraction to give the quinoline 5 by base catalyzed sulfur atom elimination. IR, 1H, 13C NMR and X-ray structural analysis confirmed the structure of the isolated new products 3 and 5.
ER -
MOHAMED, Walid Fathalla, Jaromír MAREK and Pavel PAZDERA. SYNTHESIS of 4-AMINO-3-CYANO-2-MORPHOLINOQUINOLINE. \textit{Heterocyclic Communications}. London: Freund Publishing House, 2002, vol.~2002, No~1, p.~79-82. ISSN~0793-0283.
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