| VAŠKŮ, Anna, Lenka ŠPINAROVÁ, Monika GOLDBERGOVÁ, Jan MUŽÍK, Jindřich ŠPINAR, Jiří VÍTOVEC, Jiří TOMAN a Jiří VÁCHA. Double heterozygote of two endothelin-1 gene polymorhisms (G8002A and -3A/-4A) is related to big endothelin levels in chronic heart failure. Experimental and Molecular Pathology. USA: The Human Press, 2002, roč. 2002, č. 73, s. 230-233. ISSN 0014-4800. |
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@article{403493,
author = {Vašků, Anna and Špinarová, Lenka and Goldbergová, Monika and Mužík, Jan and Špinar, Jindřich and Vítovec, Jiří and Toman, Jiří and Vácha, Jiří},
article_location = {USA},
article_number = {73},
keywords = {Endothelin gene; big endothelin and heart failure},
language = {eng},
issn = {0014-4800},
journal = {Experimental and Molecular Pathology},
title = {Double heterozygote of two endothelin-1 gene polymorhisms (G8002A and -3A/-4A) is related to big endothelin levels in chronic heart failure},
volume = {2002},
year = {2002}
}
TY - JOUR
ID - 403493
AU - Vašků, Anna - Špinarová, Lenka - Goldbergová, Monika - Mužík, Jan - Špinar, Jindřich - Vítovec, Jiří - Toman, Jiří - Vácha, Jiří
PY - 2002
TI - Double heterozygote of two endothelin-1 gene polymorhisms (G8002A and -3A/-4A) is related to big endothelin levels in chronic heart failure
JF - Experimental and Molecular Pathology
VL - 2002
IS - 73
SP - 230
EP - 230
PB - The Human Press
SN - 00144800
KW - Endothelin gene
KW - big endothelin and heart failure
N2 - The aim of the study was to focus on relationship among the associated genotype of G (8002) A and -3A/-4A endothelin-1 (ET-1) gene polymorphisms and some clinical and/ or biochemical parameters in the Czech (Caucasian) patients with chronic heart failure. 103 patients with chronic heart failure (functional class NYHA II-IV, ejection fraction <40%) were included into the study. The ET-1 gene polymorphisms were detected by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. A significant decrease of the ET-1 associated genotype AG3A4A number (double heterozygote) was observed in CHF patients with plasma big-endothelin levels above 0.7 pmol/L compared to those with the levels below 0.7 pmol/L (OR=0.19, 95% confidential interval 0.06-0.57, P=0.005, Pcorr=0.03). We proved a significant decrease of the AG3A4A genotype number in the other groups compared to the group of patients with both big endothelin and endothelin-1 levels under 0.7 pmol/L (OR=0.22, 95% confidential interval 0.07-0.79, P=0.02). Double heterozygote variant of two ET-1 gene polymorphisms is associated with significantly less risk for chronic heart failure with higher levels of big endothelin.
ER -
VAŠKŮ, Anna, Lenka ŠPINAROVÁ, Monika GOLDBERGOVÁ, Jan MUŽÍK, Jindřich ŠPINAR, Jiří VÍTOVEC, Jiří TOMAN a Jiří VÁCHA. Double heterozygote of two endothelin-1 gene polymorhisms (G8002A and -3A/-4A) is related to big endothelin levels in chronic heart failure. \textit{Experimental and Molecular Pathology}. USA: The Human Press, 2002, roč.~2002, č.~73, s.~230-233. ISSN~0014-4800.
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