An association of BMI with and A(-6)G, M235T and T174M
polymorphisms in angiotensinogen gene in essential hypertension

J 2002

An association of BMI with and A(-6)G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension

VAŠKŮ, Anna, Miroslav SOUČEK, Svatava TSCHÖPLOVÁ and Andrea STEJSKALOVÁ

Basic information

Original name

An association of BMI with and A(-6)G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension

Authors

VAŠKŮ, Anna (203 Czech Republic, guarantor), Miroslav SOUČEK (203 Czech Republic), Svatava TSCHÖPLOVÁ (203 Czech Republic) and Andrea STEJSKALOVÁ (203 Czech Republic)

Edition

Journal of Human Hypertension, Velká Británie, Nature Publishing Group, 2002, 0950-9240

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.366

RIV identification code

RIV/00216224:14110/02:00005721

Organization unit

Faculty of Medicine

UT WoS

000176625500010

Keywords in English

BMI; obesity; essential hypertension; angiotensinogen; gene polymorphism; and smoking; risk factor

Abstract

V originále

The aim of the study was to assess the existence of possible associations among frequent polymorphism in angiotensinogen gene and some risk factors for essential hypertension, especially BMI and smoking. 192 control subjects (age 45.87+/-3.0) and 206 patients with the essential hypertension (age 48.71+/- 8.42) were compared at three angiotensinogen gene polymorphisms considering BMI and smoking status. No significant differences in genotype and/or allelic distribution for either A (-6) G ATG or M235T or T174M polymorphisms between the hypertensive and control groups were proved. Significantly more hypertensives than control persons with BMI above 25 kg/m2 were observed (Pcorr=0.009), independently on sex distribution. 44.6% of smokers in control group vs. 46.0% of smokers in hypertensive groups were found. No significant difference in concurrence of BMI above 25 kg/m2 and positive smoking status between control and hypertensive subjects was found. Statistically significant differences were found between control and hypertensive subjects when compared distributions of subjects with certain genotypes of the three examined polymorphisms considering BMI (Pcorr=0.0002 for AA+AG of A(-6)G ATG, Pcorr= 0.01 for CC+CT of T(174)M ATG and Pcorr=0.01 for MT+TT of M235T ATG). No functional relations among obesity and the examined polymorphisms in vivo are known. We conclude that different distribution of BMI could influence results of analyses of angiotensinogen gene polymorphisms in essential hypertension-control studies.

Links

GA306/93/2192, research and development project

Name: Polymorfismy genů pro angiotensinogen a angiotensin I konvertasu u esenciální hypertense.

Investor: Czech Science Foundation, Polymorphisms of Genes Coding for Angiotensinogen and Angiotensin I Convertase in Essential Hypertension

GA306/96/0099, research and development project

Name: Polymorfismus genu pro endotelin - 1 (EDN 1) u esenciální hypertense

Investor: Czech Science Foundation, Polymorphism of endothelin - 1 gene (EDN 1) in essential hypertension

MSM 141100002, plan (intention)

Name: Molekulární patofyziologie multigenních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases

Citovat

VAŠKŮ, Anna, Miroslav SOUČEK, Svatava TSCHÖPLOVÁ and Andrea STEJSKALOVÁ. An association of BMI with and A(-6)G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension. Journal of Human Hypertension. Velká Británie: Nature Publishing Group, 2002, vol. 2002, No 16, p. 427-430. ISSN 0950-9240.

@article{403504,
   author = {Vašků, Anna and Souček, Miroslav and Tschöplová, Svatava and Stejskalová, Andrea},
   article_location = {Velká Británie},
   article_number = {16},
   keywords = {BMI; obesity; essential hypertension; angiotensinogen; gene polymorphism; and smoking; risk factor},
   language = {eng},
   issn = {0950-9240},
   journal = {Journal of Human Hypertension},
   title = {An association of BMI with and A(-6)G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension},
   volume = {2002},
   year = {2002}
}

TY  - JOUR
ID  - 403504
AU  - Vašků, Anna - Souček, Miroslav - Tschöplová, Svatava - Stejskalová, Andrea
PY  - 2002
TI  - An association of BMI with and A(-6)G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension
JF  - Journal of Human Hypertension
VL  - 2002
IS  - 16
SP  - 427-430
EP  - 427-430
PB  - Nature Publishing Group
SN  - 09509240
KW  - BMI
KW  - obesity
KW  - essential hypertension
KW  - angiotensinogen
KW  - gene polymorphism
KW  - and smoking
KW  - risk factor
N2  - The aim of the study was to assess the existence of possible associations among frequent polymorphism in angiotensinogen gene and some risk factors for essential hypertension, especially BMI and smoking. 192 control subjects (age 45.87+/-3.0) and 206 patients with the essential hypertension (age 48.71+/- 8.42) were compared at three angiotensinogen gene polymorphisms considering BMI and smoking status. No significant differences in genotype and/or allelic distribution for either A (-6) G ATG or M235T or T174M polymorphisms between the hypertensive and control groups were proved. Significantly more hypertensives than control persons with BMI above 25 kg/m2 were observed (Pcorr=0.009), independently on sex distribution. 44.6% of smokers in control group vs. 46.0% of smokers in hypertensive groups were found. No significant difference in concurrence of BMI above 25 kg/m2 and positive smoking status between control and hypertensive subjects was found. Statistically significant differences were found between control and hypertensive subjects when compared distributions of subjects with certain genotypes of the three examined polymorphisms considering BMI (Pcorr=0.0002 for AA+AG of A(-6)G ATG, Pcorr= 0.01 for CC+CT of T(174)M ATG and Pcorr=0.01 for MT+TT of M235T ATG). No functional relations among obesity and the examined polymorphisms in vivo are known. We conclude that different distribution of BMI could influence results of analyses of angiotensinogen gene polymorphisms in essential hypertension-control studies.
ER  -

VAŠKŮ, Anna, Miroslav SOUČEK, Svatava TSCHÖPLOVÁ and Andrea STEJSKALOVÁ. An association of BMI with and A(-6)G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension. \textit{Journal of Human Hypertension}. Velká Británie: Nature Publishing Group, 2002, vol.~2002, No~16, p.~427-430. ISSN~0950-9240.

Detailed Information on Publication Record