An association of BMI with and A(-6)G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension

VAŠKŮ, Anna, Miroslav SOUČEK, Svatava TSCHÖPLOVÁ and Andrea STEJSKALOVÁ. An association of BMI with and A(-6)G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension. Journal of Human Hypertension. Velká Británie: Nature Publishing Group, 2002, vol. 2002, No 16, p. 427-430. ISSN 0950-9240.

Basic information

• Original name: An association of BMI with and A(-6)G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension
• Authors: VAŠKŮ, Anna (203 Czech Republic, guarantor), Miroslav SOUČEK (203 Czech Republic), Svatava TSCHÖPLOVÁ (203 Czech Republic) and Andrea STEJSKALOVÁ (203 Czech Republic).
• Edition: Journal of Human Hypertension, Velká Británie, Nature Publishing Group, 2002, 0950-9240.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30201 Cardiac and Cardiovascular systems
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 1.366
• RIV identification code: RIV/00216224:14110/02:00005721
• Organization unit: Faculty of Medicine
• UT WoS: 000176625500010
• Keywords in English: BMI; obesity; essential hypertension; angiotensinogen; gene polymorphism; and smoking; risk factor
• Tags: and smoking, angiotensinogen, bmi, essential hypertension, Gene polymorphism, obesity, risk factor

Abstract

The aim of the study was to assess the existence of possible associations among frequent polymorphism in angiotensinogen gene and some risk factors for essential hypertension, especially BMI and smoking. 192 control subjects (age 45.87+/-3.0) and 206 patients with the essential hypertension (age 48.71+/- 8.42) were compared at three angiotensinogen gene polymorphisms considering BMI and smoking status. No significant differences in genotype and/or allelic distribution for either A (-6) G ATG or M235T or T174M polymorphisms between the hypertensive and control groups were proved. Significantly more hypertensives than control persons with BMI above 25 kg/m2 were observed (Pcorr=0.009), independently on sex distribution. 44.6% of smokers in control group vs. 46.0% of smokers in hypertensive groups were found. No significant difference in concurrence of BMI above 25 kg/m2 and positive smoking status between control and hypertensive subjects was found. Statistically significant differences were found between control and hypertensive subjects when compared distributions of subjects with certain genotypes of the three examined polymorphisms considering BMI (Pcorr=0.0002 for AA+AG of A(-6)G ATG, Pcorr= 0.01 for CC+CT of T(174)M ATG and Pcorr=0.01 for MT+TT of M235T ATG). No functional relations among obesity and the examined polymorphisms in vivo are known. We conclude that different distribution of BMI could influence results of analyses of angiotensinogen gene polymorphisms in essential hypertension-control studies.

Links

• GA306/93/2192, research and development project: Name: Polymorfismy genů pro angiotensinogen a angiotensin I konvertasu u esenciální hypertense.

Investor: Czech Science Foundation, Polymorphisms of Genes Coding for Angiotensinogen and Angiotensin I Convertase in Essential Hypertension

• GA306/96/0099, research and development project: Name: Polymorfismus genu pro endotelin - 1 (EDN 1) u esenciální hypertense

Investor: Czech Science Foundation, Polymorphism of endothelin - 1 gene (EDN 1) in essential hypertension

• MSM 141100002, plan (intention): Name: Molekulární patofyziologie multigenních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases