The relationship among apolipoprotein(a) polymorphisms, the
low-density lipoprotein receptor-related protein, and the very
low density lipoprotein receptor genes, and plasma
lipoprotein(A) concentration in the Czech population

J 2002

The relationship among apolipoprotein(a) polymorphisms, the low-density lipoprotein receptor-related protein, and the very low density lipoprotein receptor genes, and plasma lipoprotein(A) concentration in the Czech population

BENEŠ, Petr, Jan MUŽÍK, Jaroslav BENEDÍK, Vladimír ZNOJIL, Jiří VÁCHA et. al.

Basic information

Original name

The relationship among apolipoprotein(a) polymorphisms, the low-density lipoprotein receptor-related protein, and the very low density lipoprotein receptor genes, and plasma lipoprotein(A) concentration in the Czech population

Authors

BENEŠ, Petr (203 Czech Republic, guarantor), Jan MUŽÍK (203 Czech Republic), Jaroslav BENEDÍK (203 Czech Republic), Vladimír ZNOJIL (203 Czech Republic) and Jiří VÁCHA (203 Czech Republic)

Edition

Human Biology, Detroit, Wayne State University Press, 2002, 0018-7143

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.242

RIV identification code

RIV/00216224:14110/02:00005802

Organization unit

Faculty of Medicine

UT WoS

000174933700009

Keywords in English

apolipoprotein(a); lipoprotein(a); low density lipoprotein receptor-related protein; very low density lipoprotein receptor; genetic polymorphism

Abstract

V originále

Increased plasma concentration of lipoprotein(a) [Lp(a)] is an established independent risk factor for coronary artery disease (CAD), which is strongly genetically determined. This study was designed to investigate the relationship between the K-IV and (TTTTA)(n) apolipoprotein(a) [apo(a), protein; APOA, gene] polymorphisms, as well as the C766T low-density lipoprotein receptor-related protein (LRP) and the (CGG)(n) very low density lipoprotein receptor (VLDLR) polymorphisms on the one hand, and plasma Lp(a) levels in Czech subjects who underwent coronary angiography on the other hand. The lengths of the alleles of the APOA K-IV and (TTTTA), polymorphisms were strongly inversely correlated with plasma Lp(a) levels in univariate analysis (r = -0.41, p < 10(-4) and r = -0.20, p < 0.01, respectively). Multivariate analysis revealed significant associations between the APOA polymorphisms studied and plasma Lp(a) levels in subjects expressing only one APOA K-IV allele (p < 10(-6) for K-IV and p < 0.001 for TTTTA). In subjects expressing both APOA K-IV alleles, the multivariate analysis revealed that only the APOA K-IV alleles were inversely correlated with plasma Lp(a) levels (p < 0.001). Associations between both the LRP and VLDLR gene polymorphisms and plasma Lp(a) levels were only of borderline significance (p < 0.06 and p < 0.07, respectively) and were not confirmed in multivariate analysis. In conclusion, both APOA length polymorphisms significantly influenced plasma Lp(a) concentration in the Czech population studied, and this circumstance could explain the association in this population observed earlier between APOA (TTTTA)(n) polymorphism and CAD (Benes et al. 2000). Only a minor role in the regulation of plasma Lp(a) levels is suggested for the C766T LRP and the (CGG)(n) VLDLR polymorphisms.

Links

MSM 141100002, plan (intention)

Name: Molekulární patofyziologie multigenních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases

Citovat

BENEŠ, Petr, Jan MUŽÍK, Jaroslav BENEDÍK, Vladimír ZNOJIL and Jiří VÁCHA. The relationship among apolipoprotein(a) polymorphisms, the low-density lipoprotein receptor-related protein, and the very low density lipoprotein receptor genes, and plasma lipoprotein(A) concentration in the Czech population. Human Biology. Detroit: Wayne State University Press, 2002, vol. 74, No 1, p. 129-136. ISSN 0018-7143.

@article{403868,
   author = {Beneš, Petr and Mužík, Jan and Benedík, Jaroslav and Znojil, Vladimír and Vácha, Jiří},
   article_location = {Detroit},
   article_number = {1},
   keywords = {apolipoprotein(a); lipoprotein(a); low density lipoprotein receptor-related protein; very low density lipoprotein receptor; genetic polymorphism},
   language = {eng},
   issn = {0018-7143},
   journal = {Human Biology},
   title = {The relationship among apolipoprotein(a) polymorphisms, the low-density lipoprotein receptor-related protein, and the very low density lipoprotein receptor genes, and plasma lipoprotein(A) concentration in the Czech population},
   volume = {74},
   year = {2002}
}

TY  - JOUR
ID  - 403868
AU  - Beneš, Petr - Mužík, Jan - Benedík, Jaroslav - Znojil, Vladimír - Vácha, Jiří
PY  - 2002
TI  - The relationship among apolipoprotein(a) polymorphisms, the low-density lipoprotein receptor-related protein, and the very low density lipoprotein receptor genes, and plasma lipoprotein(A) concentration in the Czech population
JF  - Human Biology
VL  - 74
IS  - 1
SP  - 129
EP  - 129
PB  - Wayne State University Press
SN  - 00187143
KW  - apolipoprotein(a)
KW  - lipoprotein(a)
KW  - low density lipoprotein receptor-related protein
KW  - very low density lipoprotein receptor
KW  - genetic polymorphism
N2  - Increased plasma concentration of lipoprotein(a) [Lp(a)] is an established independent risk factor for coronary artery disease (CAD), which is strongly genetically determined. This study was designed to investigate the relationship between the K-IV and (TTTTA)(n) apolipoprotein(a) [apo(a), protein; APOA, gene] polymorphisms, as well as the C766T low-density lipoprotein receptor-related protein (LRP) and the (CGG)(n) very low density lipoprotein receptor (VLDLR) polymorphisms on the one hand, and plasma Lp(a) levels in Czech subjects who underwent coronary angiography on the other hand. The lengths of the alleles of the APOA K-IV and (TTTTA), polymorphisms were strongly inversely correlated with plasma Lp(a) levels in univariate analysis (r = -0.41, p < 10(-4) and r = -0.20, p < 0.01, respectively). Multivariate analysis revealed significant associations between the APOA polymorphisms studied and plasma Lp(a) levels in subjects expressing only one APOA K-IV allele (p < 10(-6) for K-IV and p < 0.001 for TTTTA). In subjects expressing both APOA K-IV alleles, the multivariate analysis revealed that only the APOA K-IV alleles were inversely correlated with plasma Lp(a) levels (p < 0.001). Associations between both the LRP and VLDLR gene polymorphisms and plasma Lp(a) levels were only of borderline significance (p < 0.06 and p < 0.07, respectively) and were not confirmed in multivariate analysis. In conclusion, both APOA length polymorphisms significantly influenced plasma Lp(a) concentration in the Czech population studied, and this circumstance could explain the association in this population observed earlier between APOA (TTTTA)(n) polymorphism and CAD (Benes et al. 2000). Only a minor role in the regulation of plasma Lp(a) levels is suggested for the C766T LRP and the (CGG)(n) VLDLR polymorphisms.
ER  -

BENEŠ, Petr, Jan MUŽÍK, Jaroslav BENEDÍK, Vladimír ZNOJIL and Jiří VÁCHA. The relationship among apolipoprotein(a) polymorphisms, the low-density lipoprotein receptor-related protein, and the very low density lipoprotein receptor genes, and plasma lipoprotein(A) concentration in the Czech population. \textit{Human Biology}. Detroit: Wayne State University Press, 2002, vol.~74, No~1, p.~129-136. ISSN~0018-7143.

Detailed Information on Publication Record