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@article{403947,
author = {Litzman, Jiří and Štouračová, Martina and Krejčí, Marcela and Thon, Vojtěch and Lokaj, Jindřich},
article_location = {Brno},
article_number = {5},
keywords = {IgA deficiency; T lymphocytes; lymphocyte subsets},
language = {eng},
issn = {1211-3395},
journal = {Scripta Medica},
title = {T-lymphocytes in IgA deficiency},
volume = {74},
year = {2001}
}
TY - JOUR
ID - 403947
AU - Litzman, Jiří - Štouračová, Martina - Krejčí, Marcela - Thon, Vojtěch - Lokaj, Jindřich
PY - 2001
TI - T-lymphocytes in IgA deficiency
JF - Scripta Medica
VL - 74
IS - 5
SP - 345
EP - 345
SN - 12113395
KW - IgA deficiency
KW - T lymphocytes
KW - lymphocyte subsets
N2 - Common variable immunodeficiency (CVID) and IgA deficiency (IgAD) are primary humoral immune deficiencies with probably similar genetic background, but clinical and laboratory manifestation is much more severe in CVID than in IgAD. The aim of this study was to determine whether some abnormalities in T-lymphocyte subsets or function previously observed in CVID are also present in IgAD patients. T-lymphocyte subsets (CD3, CD4, CD8, CD4CD45RA, CD4CD45RO, CD8CD57) were studied in 61 adult IgAD patients and 43 control healthy persons. A significant decrease in CD4+ and increase in CD8+ and CD8+CD57+ lymphocytes was observed, while no significant changes in the proportion of CD45RA+ or CD45RO+ in CD4 cells were detected. No significant changes in lymphocyte proliferation after stimulation with Phytohaemagglutinin, Concanavalin-A or tetanic toxoid were observed in 15 adult IgAD patients compared to 15 controls. Our study shows, that T-lymphocyte abnormalities are also present in IgAD patient, although not in such a broad extent as in CVID.
ER -
LITZMAN, Jiří, Martina ŠTOURAČOVÁ, Marcela KREJČÍ, Vojtěch THON and Jindřich LOKAJ. T-lymphocytes in IgA deficiency. \textit{Scripta Medica}. Brno, 2001, vol.~74, No~5, p.~345-351. ISSN~1211-3395.
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