VAŠKŮ, Vladimír, Anna VAŠKŮ, Svatava TSCHÖPLOVÁ, Lydie IZAKOVIČOVÁ HOLLÁ, Věra SEMRÁDOVÁ and Jiří VÁCHA. Genotype association of C(-735)T polymorphism in matrix metalloproteinase 2 gene with G(8002)A endothelin 1 gene with plaque psoriasis. Dermatology. Basel: Karger, 2002, vol. 204, No 4, p. 262-265. ISSN 1018-8665.
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Basic information
Original name Genotype association of C(-735)T polymorphism in matrix metalloproteinase 2 gene with G(8002)A endothelin 1 gene with plaque psoriasis
Authors VAŠKŮ, Vladimír (203 Czech Republic, guarantor), Anna VAŠKŮ (203 Czech Republic), Svatava TSCHÖPLOVÁ (203 Czech Republic), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic), Věra SEMRÁDOVÁ (203 Czech Republic) and Jiří VÁCHA (203 Czech Republic).
Edition Dermatology, Basel, Karger, 2002, 1018-8665.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.973
RIV identification code RIV/00216224:14110/02:00006175
Organization unit Faculty of Medicine
UT WoS 000176566500002
Keywords in English MMP-2; Endothelin-1; Gene polymorphism; Plaque psoriasis
Tags Endothelin-1, Gene polymorphism, MMP-2, Plaque psoriasis
Changed by Changed by: prof. MUDr. Anna Vašků, CSc., učo 122. Changed: 18/6/2009 09:58.
Abstract
Excessive angiogenesis is one of the characteristic features of psoriasis. To determine the possible genetic background of neo-angiogenesis in plaque psoriasis, frequent polymorphisms in matrix metalloproteinase 2 (MMP-2) and endothelin 1 (ET-1) genes were studied. A significant difference in genotype distribution of C(-735)T MMP-2 between psoriatic and control patients was found (pcorr=0.008). Two associated genotypes (CCGG and CTGG) of the two polymorphisms were significantly less frequent in psoriatic patients (pcorr=0.03 and pcorr=0.008, respectively). The results seem to reflect a different susceptibility of MMP-2 as well as of some associated MMP-2 and ET-1 genotypes to psoriasis.
Links
MSM 141100002, plan (intention)Name: Molekulární patofyziologie multigenních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases
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