VAŠKŮ, Vladimír, Anna VAŠKŮ, Svatava TSCHÖPLOVÁ, Lydie IZAKOVIČOVÁ HOLLÁ, Věra SEMRÁDOVÁ and Jiří VÁCHA. Genotype association of C(-735)T polymorphism in matrix metalloproteinase 2 gene with G(8002)A endothelin 1 gene with plaque psoriasis. Dermatology. Basel: Karger, 2002, vol. 204, No 4, p. 262-265. ISSN 1018-8665. |
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@article{404296, author = {Vašků, Vladimír and Vašků, Anna and Tschöplová, Svatava and Izakovičová Hollá, Lydie and Semrádová, Věra and Vácha, Jiří}, article_location = {Basel}, article_number = {4}, keywords = {MMP-2; Endothelin-1; Gene polymorphism; Plaque psoriasis}, language = {eng}, issn = {1018-8665}, journal = {Dermatology}, title = {Genotype association of C(-735)T polymorphism in matrix metalloproteinase 2 gene with G(8002)A endothelin 1 gene with plaque psoriasis}, volume = {204}, year = {2002} }
TY - JOUR ID - 404296 AU - Vašků, Vladimír - Vašků, Anna - Tschöplová, Svatava - Izakovičová Hollá, Lydie - Semrádová, Věra - Vácha, Jiří PY - 2002 TI - Genotype association of C(-735)T polymorphism in matrix metalloproteinase 2 gene with G(8002)A endothelin 1 gene with plaque psoriasis JF - Dermatology VL - 204 IS - 4 SP - 262 EP - 262 PB - Karger SN - 10188665 KW - MMP-2 KW - Endothelin-1 KW - Gene polymorphism KW - Plaque psoriasis N2 - Excessive angiogenesis is one of the characteristic features of psoriasis. To determine the possible genetic background of neo-angiogenesis in plaque psoriasis, frequent polymorphisms in matrix metalloproteinase 2 (MMP-2) and endothelin 1 (ET-1) genes were studied. A significant difference in genotype distribution of C(-735)T MMP-2 between psoriatic and control patients was found (pcorr=0.008). Two associated genotypes (CCGG and CTGG) of the two polymorphisms were significantly less frequent in psoriatic patients (pcorr=0.03 and pcorr=0.008, respectively). The results seem to reflect a different susceptibility of MMP-2 as well as of some associated MMP-2 and ET-1 genotypes to psoriasis. ER -
VAŠKŮ, Vladimír, Anna VAŠKŮ, Svatava TSCHÖPLOVÁ, Lydie IZAKOVIČOVÁ HOLLÁ, Věra SEMRÁDOVÁ and Jiří VÁCHA. Genotype association of C(-735)T polymorphism in matrix metalloproteinase 2 gene with G(8002)A endothelin 1 gene with plaque psoriasis. \textit{Dermatology}. Basel: Karger, 2002, vol.~204, No~4, p.~262-265. ISSN~1018-8665.
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