Effect of sigma ligand haloperidol in guinea pig heart preparations

NOVÁKOVÁ, Marie. Effect of sigma ligand haloperidol in guinea pig heart preparations. Journal of Molecular and Cellular Cardiology. London: Academic Press, 2002, vol. 34, No 6, p. A87, 1 pp. ISSN 0022-2828.

Basic information

• Original name: Effect of sigma ligand haloperidol in guinea pig heart preparations
• Authors: NOVÁKOVÁ, Marie (203 Czech Republic, guarantor).
• Edition: Journal of Molecular and Cellular Cardiology, London, Academic Press, 2002, 0022-2828.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30105 Physiology
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 4.091
• RIV identification code: RIV/00216224:14110/02:00006189
• Organization unit: Faculty of Medicine
• UT WoS: 000176496800316
• Keywords in English: cardiac sigma receptor; haloperidol; contractility; mechanical restitution
• Tags: cardiac sigma receptor, contractility, haloperidol, Mechanical restitution

Abstract

The effects of sigma ligand haloperidol in the multicellular guinea pig heart preparations were examined. Adult male guinea pigs were used. Left atrium and papillary muscle from right ventricle were examined. The stimulated twiches in horizontal bath were recorded isometrically. Sigma ligand haloperidol (10nM) was administered for 30 minutes. Its effect on the amplitude of contraction and on the mechanical restitution was evaluated. Marked positive inotropic effect (increase in the twitch amplitude ranging from 50 to 90 % for atria and 5 to 45% for ventricles, with maximal effect in the 5th minute of ligand administration for both preparations) has been observed. The mechanical restitution pattern under the effect of sigma receptor ligand is not altered. Thus, the positive inotropic effect of haloperidol was confirmed in guinea pig heart preparations. According to its effect on the mechanical restitution can be assumed that it is mediated via increased cytoplasmatic calcium concentration.

Links

• GA102/01/1494, research and development project: Name: Optické snímání akčních potenciálů a jeho využití v kardiologii

Investor: Czech Science Foundation, Optical recording of action potentials and its application in cardiology

• GA305/98/P206, research and development project: Name: Ovlivnění kontraktility a membránových proudů savčího myokardu prostřednictvím sigma receptorů

Investor: Czech Science Foundation, The effect of sigma receptors on contractility and membrane currents in mammalian myocardium