GOLDBERGOVÁ, Monika, Lenka ŠPINAROVÁ, Jindřich ŠPINAR, Jiří TOMAN, Anna VAŠKŮ and Jiří VÁCHA. Association of Two Angiotensinogen Gene Polymorphisms (M235T and G(-6)A) with Chronic Heart Failure. International Journal of Cardiology. Ireland: Elsevier, 2003, vol. 89, 2-3, p. 267-272. ISSN 0167-5273.
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Basic information
Original name Association of Two Angiotensinogen Gene Polymorphisms (M235T and G(-6)A) with Chronic Heart Failure
Authors GOLDBERGOVÁ, Monika (203 Czech Republic, guarantor), Lenka ŠPINAROVÁ (203 Czech Republic), Jindřich ŠPINAR (203 Czech Republic), Jiří TOMAN (203 Czech Republic), Anna VAŠKŮ (203 Czech Republic) and Jiří VÁCHA (203 Czech Republic).
Edition International Journal of Cardiology, Ireland, Elsevier, 2003, 0167-5273.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.892
RIV identification code RIV/00216224:14110/03:00008558
Organization unit Faculty of Medicine
UT WoS 000183429100018
Keywords in English Chronic heart failure; angiotensinogene gene; polymorphism
Tags angiotensinogene gene, chronic heart failure, polymorphism
Changed by Changed by: prof. RNDr. Monika Pávková Goldbergová, Ph.D., učo 9447. Changed: 22/6/2009 10:32.
Abstract
The aim of the study was to focus on relationship between the angiotensinogen (AGT) gene polymorphisms, M235T and promoter G(-6)A, and chronic heart failure in the Czech population. 158 patients with chronic heart failure (functional class NYHA II-IV, ejection fraction <40% cardiothoracic index >50%) were compared with control group of 200 subjects of similar age and sex distribution, without any personal history of cardiovascular diseases. The AGT gene polymorphisms were detected by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. No significant differences in distributions of AGT genotypes between patients with chronic heart failure (CHF) and controls were found. The differences in distributions of alleles in AGT M235T (Pa=0.02) and genotypes in AGT G(-6)A (Pg=0.017) were found within women groups. Within CHF patients the distribution of AGT G(-6)A genotypes was not consistent with Hardy-Weinberg equilibrium (P=0.0001). We found significant relative risk of CHF for GGMT genotype, OR=2.63 with 95% CI 1.39-4.95, Pcorr=0.01 (in man group OR=1.83, 95% CI 0.92-3.66, Pcorr=0.3; in woman group OR=15.5, 95% CI 1.86-129.42, Pcorr=0.008). We provide evidence of increased risk in subjects with GGMT variant of associated genotype of AGT gene for CHF, especially of fifteen-fold risk of this variant in women.
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MSM 141100002, plan (intention)Name: Molekulární patofyziologie multigenních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases
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