D 2002

Caffeic acid affects an induced differentiation process into granulocyte stage in HL-60 myeloid leukaemia cell line

VESELSKÁ, Renata, Karel ZITTERBART and Jan AUER

Basic information

Original name

Caffeic acid affects an induced differentiation process into granulocyte stage in HL-60 myeloid leukaemia cell line

Authors

VESELSKÁ, Renata (203 Czech Republic, guarantor), Karel ZITTERBART (203 Czech Republic) and Jan AUER (203 Czech Republic)

Edition

1. vyd. České Budějovice, Cells IV, p. 90-90, 2002

Publisher

Kopp Publishing

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

10600 1.6 Biological sciences

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/02:00006406

Organization unit

Faculty of Medicine

ISBN

80-7232-181-1

Keywords in English

induced differentiation; apoptosis; MTT-assay; HL-60 cell line; caffeic acid; retinoic acid; dimethyl sulfoxide

Tags

Změněno: 13/5/2003 16:26, prof. RNDr. Renata Veselská, Ph.D., M.Sc.

Abstract

V originále

The aim of presented study was to investigate possible effect of caffeic acid (CA) in combination with known differentiating agents, all-trans retinoic acid (ATRA) or dimethylsulfoxide (DMSO) respectively, on the HL-60 human myeloid leukemia cell line. Treatment of the HL-60 cells by CA in combination with known differentiation inductors ATRA and DMSO leads to the reduction of cell viability and increased frequency of apoptosis.

Links

GA304/00/0403, research and development project
Name: Změny cytoskeletu buněk nádorových linií v průběhu indukované apoptózy v závislosti na stádiu diferenciace.
Investor: Czech Science Foundation, Changes of the cytoskeleton in tumour cell lines during induced apoptosis in relation to different stages of differentiation