D 2002

Changes in the cytoskeleton of P19 cells during apoptosis associated with induced differentiation

NERADIL, Jakub, Renata VESELSKÁ and Augustin SVOBODA

Basic information

Original name

Changes in the cytoskeleton of P19 cells during apoptosis associated with induced differentiation

Authors

NERADIL, Jakub (203 Czech Republic, guarantor), Renata VESELSKÁ (203 Czech Republic) and Augustin SVOBODA (203 Czech Republic)

Edition

1. vyd. České Budějovice, Cells IV, p. 108-108, 2002

Publisher

Kopp Publishing

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

10600 1.6 Biological sciences

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/02:00006512

Organization unit

Faculty of Medicine

ISBN

80-7232-181-1

Keywords in English

induced differentiation; apoptosis; cytoskeleton; P19 cell line; retinoic acid; dimethylsulfoxide; actin filaments; microtubules

Tags

Změněno: 13/5/2003 16:27, prof. RNDr. Renata Veselská, Ph.D., M.Sc.

Abstract

V originále

The aim of the work was to study the morphology of microtubules and actin filaments during the apoptosis accompanying the differentiation of P19 cells. Mesodermal differentiation was induced by dimtehylsulfoxide and retinoic acid was used for induction of neuronal differentiation. To summarize, actin cytoskeleton actively participates in the executive phase of apoptosis whereas microtubules are only passively degraded in consequence of tubulin proteolysis.

Links

GA304/00/0403, research and development project
Name: Změny cytoskeletu buněk nádorových linií v průběhu indukované apoptózy v závislosti na stádiu diferenciace.
Investor: Czech Science Foundation, Changes of the cytoskeleton in tumour cell lines during induced apoptosis in relation to different stages of differentiation