Induced differentiation and apoptosis in HL-60 cell line modulated by caffeic acid treatment

VESELSKÁ, Renata, Karel ZITTERBART and Jan AUER. Induced differentiation and apoptosis in HL-60 cell line modulated by caffeic acid treatment. In 10th Euroconference on Apoptosis - "Charming to Death". 2002.

Basic information

• Original name: Induced differentiation and apoptosis in HL-60 cell line modulated by caffeic acid treatment
• Authors: VESELSKÁ, Renata (203 Czech Republic, guarantor), Karel ZITTERBART (203 Czech Republic) and Jan AUER (203 Czech Republic).
• Edition: 10th Euroconference on Apoptosis - "Charming to Death" 2002.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 10600 1.6 Biological sciences
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/02:00006513
• Organization unit: Faculty of Medicine
• Keywords in English: induced differentiation; apoptosis; MTT-assay; HL-60 cell line; caffeic acid; retinoic acid; dimethyl sulfoxide
• Tags: apoptosis, caffeic acid, dimethyl sulfoxide, HL-60 cell line, induced differentiation, MTT-assay, retinoic acid

Abstract

The aim of presented study was to investigate possible effect of caffeic acid (CA) in combination with known differentiating agents, all-trans retinoic acid (ATRA) or dimethylsulfoxide (DMSO) respectively, on the HL-60 human myeloid leukemia cell line. Treatment of the HL-60 cells by CA in combination with known differentiation inductors ATRA and DMSO leads to the reduction of cell viability and increased frequency of apoptosis.

Links

• GA304/00/0403, research and development project: Name: Změny cytoskeletu buněk nádorových linií v průběhu indukované apoptózy v závislosti na stádiu diferenciace.

Investor: Czech Science Foundation, Changes of the cytoskeleton in tumour cell lines during induced apoptosis in relation to different stages of differentiation