| KOZUBEK, Stanislav, Emilie LUKÁŠOVÁ, Pavla JIRSOVÁ, Irena KOUTNÁ, Michal KOZUBEK, Alena GAŇOVÁ, Eva BÁRTOVÁ, Martin FALK and Renata TASLEROVÁ. 3D Structure of the human genome: Order in randomness. Chromosoma. Berlin: Springer-Verlag, 2002, vol. 111, No 5, p. 321-331. ISSN 0009-5915. |
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@article{406042,
author = {Kozubek, Stanislav and Lukášová, Emilie and Jirsová, Pavla and Koutná, Irena and Kozubek, Michal and Gaňová, Alena and Bártová, Eva and Falk, Martin and Taslerová, Renata},
article_location = {Berlin},
article_number = {5},
keywords = {human genome structure; interphase cell nuclei},
language = {eng},
issn = {0009-5915},
journal = {Chromosoma},
title = {3D Structure of the human genome: Order in randomness},
volume = {111},
year = {2002}
}
TY - JOUR
ID - 406042
AU - Kozubek, Stanislav - Lukášová, Emilie - Jirsová, Pavla - Koutná, Irena - Kozubek, Michal - Gaňová, Alena - Bártová, Eva - Falk, Martin - Taslerová, Renata
PY - 2002
TI - 3D Structure of the human genome: Order in randomness
JF - Chromosoma
VL - 111
IS - 5
SP - 321
EP - 321
PB - Springer-Verlag
SN - 00095915
KW - human genome structure
KW - interphase cell nuclei
N2 - A complex study of the spatial arrangement of different genetic elements (genes, centromeres and chromosomal domains) in the cell nucleus is presented and the principles of this arrangement are discussed. We show that the radial location of genetic elements in the three-dimensional (3D) space between the center of the nucleus and the nuclear membrane is element specific and dependent on the position of the element on the chromosome. In contrast, mutual angular positioning of both homologous and heterologous genetic elements is, in the majority of cases, random. In several cases, tethering of heterologous genetic elements was observed. This close proximity of specific loci may be responsible for their mutual rearrangement and the development of cancer. Comparison of our results with transcriptome maps shows that the nuclear location of chromosomal domains with highly expressed genes is more central when compared with chromosomes with low expression. The higher-order chromatin structure is strikingly similar in various human cell types, which correlates with the fact that the profiles of gene expression are also similar.
ER -
KOZUBEK, Stanislav, Emilie LUKÁŠOVÁ, Pavla JIRSOVÁ, Irena KOUTNÁ, Michal KOZUBEK, Alena GAŇOVÁ, Eva BÁRTOVÁ, Martin FALK and Renata TASLEROVÁ. 3D Structure of the human genome: Order in randomness. \textit{Chromosoma}. Berlin: Springer-Verlag, 2002, vol.~111, No~5, p.~321-331. ISSN~0009-5915.
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