BERÁNEK, Michal, Svatava TSCHÖPLOVÁ, Kateřina KAŇKOVÁ, Viera KUHROVÁ and Jiří VÁCHA. Genetic variation in the promoter region of the basic Fibroblast Growth Factor gene (bFGF). Human Immunology. USA: ELSEVIER SCIENCE INC, 2002, vol. 64, No 3, p. 374-377. ISSN 0198-8859.
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Basic information
Original name Genetic variation in the promoter region of the basic Fibroblast Growth Factor gene (bFGF)
Authors BERÁNEK, Michal (203 Czech Republic, guarantor), Svatava TSCHÖPLOVÁ (203 Czech Republic), Kateřina KAŇKOVÁ (203 Czech Republic), Viera KUHROVÁ (203 Czech Republic) and Jiří VÁCHA (203 Czech Republic).
Edition Human Immunology, USA, ELSEVIER SCIENCE INC, 2002, 0198-8859.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.573
RIV identification code RIV/00216224:14110/02:00006679
Organization unit Faculty of Medicine
UT WoS 000181137600008
Keywords in English bFGF; genetic polymorphism; linkage disequilibrium
Tags bFGF, genetic polymorphism, linkage disequilibrium
Changed by Changed by: prof. MUDr. Kateřina Kaňková, Ph.D., učo 2524. Changed: 24/6/2009 15:25.
Abstract
Basic fibroblast growth factor (bFGF) is a member of the fibroblast growth factor family that possess broad mitogenic and cell survival activities and is involved in a variety of biological processes. We investigated possible genetic polymorphism in the promoter and 5 flanking region of the bFGF gene. Polymorphism was analysed by means of heteroduplex analysis, fragments with altered mobility were sequenced. Three novel substitutions (-553T/A, -834T/A and -921C/G) were identified in the promoter region. Allele frequencies in a sample of healthy Caucasian subjects (n=126) were determined by polymerase chain reactions followed by restriction analyses with specific endonucleases. The frequencies of the mutated alleles (-553A, -834A and 921G) were 0.04, 0.05 and 0.14, respectively. Newly identified variants in the bFGF gene promoter appear to be common polymorphisms in the Czech population.
Links
MSM 141100002, plan (intention)Name: Molekulární patofyziologie multigenních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases
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