NMR of Nucleic Acids

FIALA, Radovan and Vladimír SKLENÁŘ. NMR of Nucleic Acids. In ZERBE, Oliver. BioNMR in Drug Research. 1st ed. Weinheim: Wiley-VCH, 2002, p. 121-145. Methods and Principles in Medicinal Chemistry. ISBN 3-527-30465-7.

Basic information

Original name

NMR of Nucleic Acids

Authors

FIALA, Radovan (203 Czech Republic) and Vladimír SKLENÁŘ (203 Czech Republic, guarantor)

Edition

1. vyd. Weinheim, BioNMR in Drug Research, p. 121-145, Methods and Principles in Medicinal Chemistry, 2002

Publisher

Wiley-VCH

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Other information

Language

English

Type of outcome

Kapitola resp. kapitoly v odborné knize

Field of Study

10600 1.6 Biological sciences

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

RIV identification code

RIV/00216224:14310/02:00006909

Organization unit

Faculty of Science

ISBN

3-527-30465-7

Keywords in English

NMR; nuclear magnetic resonance; nucleic acid; DNA; RNA; structure; dynamics

Tags

DNA, dynamics, NMR, nuclear magnetic resonance, nucleic acid, RNA, structure

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Abstract

V originále

The paper concentrates primarily on the recent development of the high-resolution NMR techniques that have shown potential of increasing the range of promising applications and capability to provide new structural information. These include the 2H, 13C, and 15N isotope-labeling techniques for RNA and DNA, sensitivity optimized multi-dimensional NMR experiments, techniques to detect hydrogen-bond networks, applications of residual dipolar couplings for extracting structural restrains, and relaxation studies providing the information on dynamics and structure.

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Links

LN00A016, research and development project

Name: BIOMOLEKULÁRNÍ CENTRUM Investor: Ministry of Education, Youth and Sports of the CR, Biomolecular Center