NAVRÁTILOVÁ, Jarmila, Sabina ŠEVČÍKOVÁ and Jan ŠMARDA. Roscovitine-stabilized p53 suppresses growth and induces differentiation of v-myb-transformed monoblasts. In Cells IV. České Budějovice: Kopp Publishing, 2002. p. 95. Cells IV. ISBN 80-7232-181-1.
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Basic information
Original name Roscovitine-stabilized p53 suppresses growth and induces differentiation of v-myb-transformed monoblasts
Authors NAVRÁTILOVÁ, Jarmila (203 Czech Republic), Sabina ŠEVČÍKOVÁ (203 Czech Republic) and Jan ŠMARDA (203 Czech Republic, guarantor).
Edition České Budějovice, Cells IV, p. 95-95, Cells IV, 2002.
Publisher Kopp Publishing
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 30200 3.2 Clinical medicine
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14310/02:00006911
Organization unit Faculty of Science
ISBN 80-7232-181-1
Keywords in English p53; Myb; differentiation; proliferation; roscovitine
Tags differentiation, Myb, p53, proliferation, roscovitine
Changed by Changed by: prof. RNDr. Jan Šmarda, CSc., učo 1223. Changed: 11/12/2002 13:05.
BM2 monoblasts constitutively express v-myb oncogene and their terminal differentiation steps are blocked. However, using phorbol esters the terminal differentiation can be resumed. We wished to explore the role of p53 in regulation of differentiation, proliferation and apoptosis of BM2 cells. We inducibly expressed human p53 in chicken BM2 cells. Upon stabilization using roscovitine the p53 protein was capable to suppress growth and induce terminal differentiation of BM2 cells.
MSM 143100008, plan (intention)Name: Genomy a jejich funkce
Investor: Ministry of Education, Youth and Sports of the CR, Genomes and their functions
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