Detailed Information on Publication Record
2002
Roscovitine-stabilized p53 suppresses growth and induces differentiation of v-myb-transformed monoblasts
NAVRÁTILOVÁ, Jarmila, Sabina ŠEVČÍKOVÁ and Jan ŠMARDABasic information
Original name
Roscovitine-stabilized p53 suppresses growth and induces differentiation of v-myb-transformed monoblasts
Authors
NAVRÁTILOVÁ, Jarmila (203 Czech Republic), Sabina ŠEVČÍKOVÁ (203 Czech Republic) and Jan ŠMARDA (203 Czech Republic, guarantor)
Edition
České Budějovice, Cells IV, p. 95-95, Cells IV, 2002
Publisher
Kopp Publishing
Other information
Language
English
Type of outcome
Stať ve sborníku
Field of Study
30200 3.2 Clinical medicine
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14310/02:00006911
Organization unit
Faculty of Science
ISBN
80-7232-181-1
Keywords in English
p53; Myb; differentiation; proliferation; roscovitine
Tags
Změněno: 11/12/2002 13:05, prof. RNDr. Jan Šmarda, CSc.
Abstract
V originále
BM2 monoblasts constitutively express v-myb oncogene and their terminal differentiation steps are blocked. However, using phorbol esters the terminal differentiation can be resumed. We wished to explore the role of p53 in regulation of differentiation, proliferation and apoptosis of BM2 cells. We inducibly expressed human p53 in chicken BM2 cells. Upon stabilization using roscovitine the p53 protein was capable to suppress growth and induce terminal differentiation of BM2 cells.
Links
MSM 143100008, plan (intention) |
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