D 2002

Roscovitine-stabilized p53 suppresses growth and induces differentiation of v-myb-transformed monoblasts

NAVRÁTILOVÁ, Jarmila, Sabina ŠEVČÍKOVÁ and Jan ŠMARDA

Basic information

Original name

Roscovitine-stabilized p53 suppresses growth and induces differentiation of v-myb-transformed monoblasts

Authors

NAVRÁTILOVÁ, Jarmila (203 Czech Republic), Sabina ŠEVČÍKOVÁ (203 Czech Republic) and Jan ŠMARDA (203 Czech Republic, guarantor)

Edition

České Budějovice, Cells IV, p. 95-95, Cells IV, 2002

Publisher

Kopp Publishing

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/02:00006911

Organization unit

Faculty of Science

ISBN

80-7232-181-1

Keywords in English

p53; Myb; differentiation; proliferation; roscovitine
Změněno: 11/12/2002 13:05, prof. RNDr. Jan Šmarda, CSc.

Abstract

V originále

BM2 monoblasts constitutively express v-myb oncogene and their terminal differentiation steps are blocked. However, using phorbol esters the terminal differentiation can be resumed. We wished to explore the role of p53 in regulation of differentiation, proliferation and apoptosis of BM2 cells. We inducibly expressed human p53 in chicken BM2 cells. Upon stabilization using roscovitine the p53 protein was capable to suppress growth and induce terminal differentiation of BM2 cells.

Links

MSM 143100008, plan (intention)
Name: Genomy a jejich funkce
Investor: Ministry of Education, Youth and Sports of the CR, Genomes and their functions