Roscovitine-stabilized p53 suppresses growth and induces differentiation of v-myb-transformed monoblasts

NAVRÁTILOVÁ, Jarmila, Sabina ŠEVČÍKOVÁ and Jan ŠMARDA. Roscovitine-stabilized p53 suppresses growth and induces differentiation of v-myb-transformed monoblasts. In Cells IV. České Budějovice: Kopp Publishing. p. 95. Cells IV. ISBN 80-7232-181-1. 2002.

Basic information

• Original name: Roscovitine-stabilized p53 suppresses growth and induces differentiation of v-myb-transformed monoblasts
• Authors: NAVRÁTILOVÁ, Jarmila (203 Czech Republic), Sabina ŠEVČÍKOVÁ (203 Czech Republic) and Jan ŠMARDA (203 Czech Republic, guarantor).
• Edition: České Budějovice, Cells IV, p. 95-95, Cells IV, 2002.
• Publisher: Kopp Publishing

Other information

• Original language: English
• Type of outcome: Proceedings paper
• Field of Study: 30200 3.2 Clinical medicine
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14310/02:00006911
• Organization unit: Faculty of Science
• ISBN: 80-7232-181-1
• Keywords in English: p53; Myb; differentiation; proliferation; roscovitine
• Tags: differentiation, Myb, p53, proliferation, roscovitine

Abstract

BM2 monoblasts constitutively express v-myb oncogene and their terminal differentiation steps are blocked. However, using phorbol esters the terminal differentiation can be resumed. We wished to explore the role of p53 in regulation of differentiation, proliferation and apoptosis of BM2 cells. We inducibly expressed human p53 in chicken BM2 cells. Upon stabilization using roscovitine the p53 protein was capable to suppress growth and induce terminal differentiation of BM2 cells.

Links

• MSM 143100008, plan (intention): Name: Genomy a jejich funkce

Investor: Ministry of Education, Youth and Sports of the CR, Genomes and their functions