Effects of endocannabinoids on agonistic behaviour in mice

NOVÁKOVÁ, Jana, Jana VINKLEROVÁ and Alexandra ŠULCOVÁ. Effects of endocannabinoids on agonistic behaviour in mice. Adiktologie. Tišnov: Sdružení SCAN, 2002, vol. 2, Suppl.1, p. 68-69. ISSN 1213-3841.

Basic information

Original name

Effects of endocannabinoids on agonistic behaviour in mice

Authors

NOVÁKOVÁ, Jana (203 Czech Republic, guarantor), Jana VINKLEROVÁ (203 Czech Republic) and Alexandra ŠULCOVÁ (203 Czech Republic)

Edition

Adiktologie, Tišnov, Sdružení SCAN, 2002, 1213-3841

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/02:00006943

Organization unit

Faculty of Medicine

Keywords in English

CB1 and CB2 cannabinoid receptor subtypes; endocannabinoids; agonistic behaviour; mice

Tags

agonistic behaviour, endocannabinoids, mice

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Abstract

V originále

The present study was designed to ascertain behavioural effects of novel endocannabinoid ligand noladin ether using the model of agonistic behaviour in mice. In aggressive singly-housed mice, noladin did not show marked changes in behavioural activities. The only significant effect recorded was the significant inhibition of sociable sniffing. In timid isolates, noladin elicited a significant aggresssogenic action with the impairment of the locomotor activity. Thus, the behavioural noladin profile found did not fully resemble that of anandamide which in our earlier experiments exerted a significant antiaggressive effects using the model of mouse agonistic social interactions.