FAJKUS, Jiří, Marta ŠIMÍČKOVÁ and Jan MALÁSKA. Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology. Phil. Trans. R. Soc. Lond. B. London: ROYAL SOC LONDON, 2002, roč. 357, April, p. 545-562. ISSN 0962-8436. |
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@article{407396, author = {Fajkus, Jiří and Šimíčková, Marta and Maláska, Jan}, article_location = {London}, article_number = {April}, keywords = {human telomere; telomerase regulation; cancer; inhibiotin; cell engineering; tissue engineering}, language = {eng}, issn = {0962-8436}, journal = {Phil. Trans. R. Soc. Lond. B}, title = {Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology}, volume = {roč. 357}, year = {2002} }
TY - JOUR ID - 407396 AU - Fajkus, Jiří - Šimíčková, Marta - Maláska, Jan PY - 2002 TI - Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology JF - Phil. Trans. R. Soc. Lond. B VL - roč. 357 IS - April SP - 545 EP - 545 PB - ROYAL SOC LONDON SN - 09628436 KW - human telomere KW - telomerase regulation KW - cancer KW - inhibiotin KW - cell engineering KW - tissue engineering N2 - The past decade has witnessed an explosion of knowledge concerning the structure and function of chromosome terminal structures-telomeres. Today's telomere research has advanced from a pure descriptive approach of DNA and protein components to an elementary understanding of telomere metabolism, and now to promising applications in medicine. These applications include 'passive' ones, among which the use of analysis of telomeres and telomerase for cancer diagnostics is the best known. The 'active' applications involve targeted downregulation or upregulation of telomere synthesis, either to mortalize immortal cancer cells, or to rejuvenate mortal somatic cells and tissues for cellular transplantations , respectively. ER -
FAJKUS, Jiří, Marta ŠIMÍČKOVÁ and Jan MALÁSKA. Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology. \textit{Phil. Trans. R. Soc. Lond. B}. London: ROYAL SOC LONDON, 2002, roč. 357, April, p.~545-562. ISSN~0962-8436.
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